Protein Alignment GDF11 and mav

DIOPT Version :10

• Sequence 1: NP_005802.1
• Gene: GDF11 / 10220
• HGNCID: 4216
• Length: 407
• Species: Homo sapiens
• Sequence 2: NP_524626.1
• Gene: mav / 43804
• FlyBaseID: FBgn0039914
• Length: 701
• Species: Drosophila melanogaster
• Alignment Length: 252
• Identity: 62/252 - (24%)
• Similarity: 94/252 - (37%)
• Gaps: 69/252 - (27%)

Human   217 RHIRIRSLKIEL------HSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINA-------------F 262
            |..:|.|.|||.      .:|: .|...|..:.:.||..:...|.||||..             |
  Fly   458 RRRKITSRKIEFGNVGFQETRT-QWIEFDVTKAVRSWLNKSHENLGIEIQCDKCKSIGARILSDF 521

Human   263 DPS------------------------GTDLAVTSLGPGAEGLHPFMELRVLENTK-------RS 296
            .||                        ||   :.|...|...:|..|    |.|.:       ||
  Fly   522 SPSTPPRSTASSDEHLNLMPVLNIIGHGT---LNSQQHGDADIHQIM----LTNNRSDQYVHHRS 579

Human   297 RRNLGLDCDE-----HSSESRCCRYPLTVDFEAF-GWDWIIAPKRYKANYCSGQCEYMFMQKYPH 355
            ..:.....|:     :....||||..|.|.|::. |:::|:.||.:.|.||.|:|.......:.|
  Fly   580 NHDSTWRKDKWTNNCYKLHQRCCRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRCPPRHNPAHHH 644

Human   356 T---HLVQQANPRGSAGPCCTPTKMSPINMLYF--NDKQQIIYGKIPGMVVDRCGCS 407
            .   .|:.|.:.:.:..|||||:|:..:.:|:.  |...::.......|.|..|.||
  Fly   645 ALLQSLIWQEDHKRAPRPCCTPSKLEMLEILHVDENHSDKLKISTWSDMQVVECACS 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GDF11	NP_005802.1	TGFb_propeptide	61..285	CDD:480997	24/110 (22%)
		TGF_beta_GDF8	301..407	CDD:381658	31/116 (27%)
mav	NP_524626.1	TGFb_propeptide	<438..518	CDD:480997	16/60 (27%)
		TGF_beta_maverick	598..700	CDD:381633	30/101 (30%)