Protein Alignment GDF11 and gbb

DIOPT Version :10

• Sequence 1: NP_005802.1
• Gene: GDF11 / 10220
• HGNCID: 4216
• Length: 407
• Species: Homo sapiens
• Sequence 2: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Alignment Length: 488
• Identity: 108/488 - (22%)
• Similarity: 172/488 - (35%)
• Gaps: 126/488 - (25%)

Human     1 MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGV----GGERSSRPAPSVAPEPDG 61
            :.:.|.|.||.:||..            .|....|..|..:|:    |.:::
  Fly    11 VAVLASLGLGMVLLMF------------VATTPPAVEATQSGIYIDNGKDQT------------- 50

Human    62 CPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHD--FQGDAL 124
               .:.|..|.:.:|: :..:||..|.:.|.|.........|...||..  :||::.  ...:.|
  Fly    51 ---IMHRVLSEDDKLD-VSYEILEFLGIAERPTHLSSHQLSLRKSAPKF--LLDVYHRITAEEGL 109

Human   125 QPEDFLEEDEYHATTETVISMAQETDPAVQ------------TDGSPLCCHF----HFSPKVMFT 173
            ..:|  |:|:|.....:..|...|.|...|            .|.|.:...|    |.:     .
  Fly   110 SDQD--EDDDYERGHRSRRSADLEEDEGEQQKNFITDLDKRAIDESDIIMTFLNKRHHN-----V 167

Human   174 KVLK----AQLWVYLRPVPRPATVYLQILRLKPLTGEG---TAGGGGGGRRHIRIRSLKIELHSR 231
            ..|:    .:||..:..||....:.:..||:.....||   ||      .|...|....|...:.
  Fly   168 DELRHEHGRRLWFDVSNVPNDNYLVMAELRIYQNANEGKWLTA------NREFTITVYAIGTGTL 226

Human   232 SGH----------------WQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGA-- 278
            ..|                |..::..:.||.|..:.:.|.||.|.|...:..|..|.....|.
  Fly   227 GQHTMEPLSSVNTTGDYVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDREVKLDDIGLIH 291

Human   279 ----EGLHPFM-------EL-------------RVLENTKRSRRNL---GLDCDEHSSESRCCR- 315
                :...|||       ||             |...:.::.::::   .:...|....:|.|:
  Fly   292 RKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRSASHPRKRKKSVSPNNVPLLEPMESTRSCQM 356

Human   316 YPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQANPRGSAGPCCT 373
            ..|.:||:..|| ||||||:.|.|.||||:|.:........|:      ||....|:....|||.
  Fly   357 QTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCA 421

Human   374 PTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
            ||::..:.:||..:.:.:...|...|:|..|||
  Fly   422 PTRLGALPVLYHLNDENVNLKKYRNMIVKSCGC 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GDF11	NP_005802.1	TGFb_propeptide	61..285	CDD:480997	54/270 (20%)
		TGF_beta_GDF8	301..407	CDD:381658	38/114 (33%)
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	57/291 (20%)
		TGF_beta_BMP5_like	353..455	CDD:381639	36/102 (35%)