DRSC/TRiP Functional Genomics Resources

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Protein Alignment GDF11 and daw

DIOPT Version :10

Sequence 1:NP_005802.1 Gene:GDF11 / 10220 HGNCID:4216 Length:407 Species:Homo sapiens
Sequence 2:NP_523461.1 Gene:daw / 33474 FlyBaseID:FBgn0031461 Length:586 Species:Drosophila melanogaster


Alignment Length:417 Identity:104/417 - (24%)
Similarity:165/417 - (39%) Gaps:101/417 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    45 GERSSRPAPSVAPEPDGCPVC--------VWRQHSRELRLESIKSQILSKLRLKEAPNISREVVK 101
            |||:.  ..||.....|||.|        :..:....||:|.:|.|||.||||||:|.:|  .|:
  Fly   215 GERNI--TISVKSSAGGCPKCESNRQVEHITEEQLTHLRIEFVKQQILEKLRLKESPKVS--AVE 275

Human   102 QLLPKAPPLQQILDLHDFQGDAL-QPEDFL---EEDEYHATT--ETVISMAQETDPAVQTDGSPL 160
              |||  |:        |.|..| .|:|..   |.|:|:|.|  :.::...:|.:.....||.. 
  Fly   276 --LPK--PI--------FDGMTLSHPDDSTKNKELDDYYARTSKKFILLNREEVECNRARDGKS- 327

Human   161 CCHFHFSPKVMFT-----------KVLKAQLWVYLRPVPRPATVYL-----------------QI 197
                  :|.:.||           .|..|.||::.....|..|..:                 |.
  Fly   328 ------NPSMCFTFKIDDADAEGFDVSTAVLWLFKNKQNRTDTASVNSTSAQQTIVVSEVEVDQQ 386

Human   198 LRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAF 262
            ...|.|:...|          |.|:|:.::     ..|..||.:..:..|....:.:..|:|.. 
  Fly   387 KDSKYLSAAKT----------IAIQSVNVQ-----DEWMKIDIEWPIKHWISGHELSHLIQITC- 435

Human   263 DPSGTDLA----VTSLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFE 323
              .|.|::    :.|:.   :...||:.:.:....::||:...::|.  |..:.|||..|.:.|.
  Fly   436 --GGCDVSDMEEIISVD---KDYRPFIVIDMQNRRRKSRQKRSINCS--SGMTECCREHLYISFR 493

Human   324 AFGW-DWIIAPKRYKANYCSGQCEYM--FMQKYPHTHLVQQ------ANPRGSAGPCCTPTKMSP 379
            ..|| :||:.|:.|.|.:|.|.|..:  ..|...|...:.:      ||......||||..:.|.
  Fly   494 DIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHHSSIMKILSTSGANKSLELVPCCTAKQYSS 558

Human   380 INMLYFNDKQQIIYGKIPGMVVDRCGC 406
            :.::..:.........:|.|||:.|||
  Fly   559 LQLVVMDSSNTATVKTLPNMVVESCGC 585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GDF11NP_005802.1 TGFb_propeptide 61..285 CDD:480997 63/269 (23%)
TGF_beta_GDF8 301..407 CDD:381658 33/115 (29%)
dawNP_523461.1 TGF_beta_INHB 483..585 CDD:381630 29/101 (29%)

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