Protein Alignment GDF11 and dpp

DIOPT Version :10

• Sequence 1: NP_005802.1
• Gene: GDF11 / 10220
• HGNCID: 4216
• Length: 407
• Species: Homo sapiens
• Sequence 2: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Alignment Length: 427
• Identity: 99/427 - (23%)
• Similarity: 155/427 - (36%)
• Gaps: 85/427 - (19%)

Human    34 AAAAAAAAGVGGERSSRPA---PSVAPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNI 95
            |.|.|..|..|....|:.|   ..:.|:|.              .|..|:..:||...:|..|.|
  Fly   192 ANAKAIIAEQGPSTYSKEALIKDKLKPDPS--------------TLVEIEKSLLSLFNMKRPPKI 242

Human    96 SREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPL 160
            .|.  |.::|:  |::::  ..:..|..|...:..:......:..||.|...: |..:. |..|.
  Fly   243 DRS--KIIIPE--PMKKL--YAEIMGHELDSVNIPKPGLLTKSANTVRSFTHK-DSKID-DRFPH 299

Human   161 CCHF--HFSPK-VMFTKVLKAQLWVYLRPVPRPATVYLQI----LRLKPLTGEGTAGGGGGGRR- 217
            ...|  ||..| :...:.|||......|.......|..:.    .|.:.|..:.|..|..|.|.
  Fly   300 HHRFRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREP 364

Human   218 -HIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGA--- 278
             ::.:.:..:.|:|..  ..|:|.:..:..|...||.|:|:.:..       ..|.||.|..
  Fly   365 SYLLLDTKTVRLNSTD--TVSLDVQPAVDRWLASPQRNYGLLVEV-------RTVRSLKPAPHHH 420

Human   279 --------------------------EGLHPFMELRVLENTK------RSRRNLGLDCDEHSSES 311
                                      :|.|....:|.:...:      |::|.........:.:.
  Fly   421 VRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHDD 485

Human   312 RCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQANPRGSAG 369
            .|.|:.|.|||...|| |||:||..|.|.||.|:|.:.....:..|:      ||...||.....
  Fly   486 TCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPK 550

Human   370 PCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
            .||.||::..:.|||.||:..::......|.|..|||
  Fly   551 ACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGC 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GDF11	NP_005802.1	TGFb_propeptide	61..285	CDD:480997	49/261 (19%)
		TGF_beta_GDF8	301..407	CDD:381658	38/113 (34%)
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:480997	46/235 (20%)
		TGF_beta_DPP	480..588	CDD:381662	38/108 (35%)