DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDK7 and KIN28

DIOPT Version :9

Sequence 1:	NP_001790.1	Gene:	CDK7 / 1022	HGNCID:	1778	Length:	346	Species:	Homo sapiens
Sequence 2:	NP_010175.1	Gene:	KIN28 / 851450	SGDID:	S000002266	Length:	306	Species:	Saccharomyces cerevisiae

Alignment Length:	296	Identity:	143/296 - (48%)
Similarity:	199/296 - (67%)	Gaps:	10/296 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76
            |.|...:|||.:|.||.....:|.:.:|||:||   .||.|||::.:|:||:|.|||:.|||:|.
Yeast     7 YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIK---TSEFKDGLDMSAIREVKYLQEMQHPNVIE 68

Human    77 LLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPN 141
            |:|.|....|::||.:|:.|||||:|||.|::.||:.|||:|||||:|:.:.|:::|||||||||
Yeast    69 LIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPN 133

Human   142 NLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAEL 206
            |||...:|.:|:||||||::..:|:...|..|||||||||||||||:.|...:|:|:||.|.|||
Yeast   134 NLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAEL 198

Human   207 LLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIP-----LHHIFSAAGD 266
            :||:|:|||.:|:||:...|..|||||:..||::.|...|...:.:|  |     |...|.||.:
Yeast   199 MLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYP--PPSRDELRKRFIAASE 261

Human   267 DLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302
            ..||.:.|:...||..|.||.|.|:..||...|.|:
Yeast   262 YALDFMCGMLTMNPQKRWTAVQCLESDYFKELPPPS 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDK7	NP_001790.1	STKc_CDK7	11..308	CDD:270833	143/296 (48%)
KIN28	NP_010175.1	STKc_CDK7	7..302	CDD:270833	143/296 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159046519
Domainoid	1	1.000	278	1.000	Domainoid score	I299
eggNOG	1	0.900	-	-		E1_KOG0659
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1363
Inparanoid	1	1.050	284	1.000	Inparanoid score	I630
Isobase	1	0.950	-	0	Normalized mean entropy	S506
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003675
OrthoInspector	1	1.000	-	-		oto144782
orthoMCL	1	0.900	-	-		OOG6_103547
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R249
SonicParanoid	1	1.000	-	-		X2548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.730