Protein Alignment DDX39A and eIF4A

DIOPT Version :10

• Sequence 1: NP_005795.2
• Gene: DDX39A / 10212
• HGNCID: 17821
• Length: 427
• Species: Homo sapiens
• Sequence 2: NP_476595.1
• Gene: eIF4A / 33835
• FlyBaseID: FBgn0001942
• Length: 403
• Species: Drosophila melanogaster
• Alignment Length: 407
• Identity: 151/407 - (37%)
• Similarity: 242/407 - (59%)
• Gaps: 14/407 - (3%)

Human    16 EEEPQAPQESTPA--PPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQA 78
            ::..:.||:. ||  .|:..|:.::..::.: |.|..|:.||||.|...|||.||.:|...|...
  Fly     2 DDRNEIPQDG-PASMEPEGVIESTWHEVYDN-FDDMNLREELLRGIYGYGFEKPSAIQQRAIIPC 64

Human    79 ILGMDVLCQAKSGMGKTAVFVLATLQQIEPVNGQVTVLVMCHTRELAFQISKEYERFSKYMPSVK 143
            :.|.||:.||:||.||||.|.:|.||||:....:...|::..|||||.||.:......:|| .|.
  Fly    65 VRGRDVIAQAQSGTGKTATFSIAILQQIDTSIRECQALILAPTRELATQIQRVVMALGEYM-KVH 128

Human   144 VSVFFGGLSIKKDEEVLKKNCPHVVVGTPGRILALVRNRSFSLKNVKHFVLDECDKMLEQLDMRR 208
            .....||.::::|..:|:..| |||||||||:..::..:....:.:|.|||||.|:||.: ..:.
  Fly   129 SHACIGGTNVREDARILESGC-HVVVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSR-GFKD 191

Human   209 DVQEIFRLTPHEKQCMMFSATLSKDIRPVCRKFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEK 273
            .:|::|::.|.:.|.::.|||:..|:..|.|.||:||:.:.|..| :|||.|::|:||.:|  ::
  Fly   192 QIQDVFKMLPPDVQVILLSATMPPDVLEVSRCFMRDPVSILVKKE-ELTLEGIKQFYVNVK--QE 253

Human   274 NRK---LFDLLDVLEFNQVIIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDF 335
            |.|   |.||.|.|...|.:||..:.::...|.|.:...||...|:|..|.|.:|....:||:..
  Fly   254 NWKLGTLCDLYDTLSITQSVIFCNTRRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRSG 318

Human   336 QRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILN 400
            ..|:|:.|:|..||:|:::|::|.|||:|.:.:.|:||:.|.||||.||:||.|::|: |.:||.
  Fly   319 SSRVLITTDLLARGIDVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGVAINFITDD-DRRILK 382

Human   401 DVQDRFEVNVAELPEEI 417
            |::..:...:.|:|..|
  Fly   383 DIEQFYHTTIEEMPANI 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX39A	NP_005795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		5/19 (26%)
		DEADc_DDX39	43..250	CDD:350708	80/206 (39%)
		Q motif	44..72		13/27 (48%)
		DECD box	195..198		2/2 (100%)
		SF2_C_DEAD	261..390	CDD:350174	50/131 (38%)
eIF4A	NP_476595.1	DEAD-like_helicase_N	6..403	CDD:475120	151/403 (37%)