Protein Alignment DDX39A and Dbp80

DIOPT Version :10

• Sequence 1: NP_005795.2
• Gene: DDX39A / 10212
• HGNCID: 17821
• Length: 427
• Species: Homo sapiens
• Sequence 2: NP_001263168.1
• Gene: Dbp80 / 3354919
• FlyBaseID: FBgn0024804
• Length: 481
• Species: Drosophila melanogaster
• Alignment Length: 414
• Identity: 125/414 - (30%)
• Similarity: 198/414 - (47%)
• Gaps: 38/414 - (9%)

Human    23 QESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILG--MDVL 85
            |:..|..|...:| ::.::|        ||..||:.|...||..||::|...:|..:..  .:::
  Fly    61 QQKNPNSPLHSVK-TFEALH--------LKASLLKGIYAMGFNTPSKIQETALPTLLADPPQNMI 116

Human    86 CQAKSGMGKTAVFVLATLQQIEPVNGQVTVLVMCHTRELAFQISKEYERFSKYMPSVKVSVFFGG 150
            .|::||.||||.||||.|.::........||.:..|.|||.|..:...|..::...:|:.....|
  Fly   117 AQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQTGEVAARMGQFCREIKLRFAVRG 181

Human   151 LSI---KKDEEVLKKNCPHVVVGTPGRILAL-VRNRSFSLKNVKHFVLDECDKMLEQLDMRRDVQ 211
            ..:   ||.||       |:::||||::|.. ::.|.|.:|.:..|||||.|.|:..........
  Fly   182 EEVDRSKKIEE-------HILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADVMIATQGHHDQCI 239

Human   212 EIFR-LTPHEKQCMMFSATLSKDIRPVCRKFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSE-KN 274
            .|.: |.|| .|.:.||||..|::....|..:.||..:.:..|.: :|..::|||||.|:.| |.
  Fly   240 RIHKMLNPH-CQMLFFSATYGKEVMDFARLIVADPTIIRLMREEE-SLENIKQYYVKCKNEEGKY 302

Human   275 RKLFDLLDVLEFNQVIIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDFQRRI 339
            ..:.::...:...|.|||..:.:....||..:.........:...:...:||....:|:....::
  Fly   303 NAIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKV 367

Human   340 LVATNLFGRGMDIERVNIVFNYDMPEDSD------TYLHRVARAGRFG----TKGLAITFVSDEN 394
            |:.||:..||:|||:|.||.|:|:|.|.|      |||||:.|.|||.    |:...|..|..|:
  Fly   368 LITTNILSRGIDIEQVTIVVNFDLPVDLDGMADCETYLHRIGRTGRFEPSALTRNSPIFGVKAES 432

Human   395 D--AKILNDVQDRFEVNVAELPEE 416
            .  .|.:|......|....|:|:|
  Fly   433 GKIGKEINRSSSGAESGSREMPKE 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX39A	NP_005795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		3/10 (30%)
		DEADc_DDX39	43..250	CDD:350708	66/213 (31%)
		Q motif	44..72		9/27 (33%)
		DECD box	195..198		2/2 (100%)
		SF2_C_DEAD	261..390	CDD:350174	44/139 (32%)
Dbp80	NP_001263168.1	DEADc_DDX19_DDX25	80..277	CDD:350721	66/204 (32%)
		SF2_C_DEAD	288..414	CDD:350174	40/125 (32%)