Protein Alignment FLOT1 and Flo2

DIOPT Version :9

• Sequence 1: NP_005794.1
• Gene: FLOT1 / 10211
• HGNCID: 3757
• Length: 427
• Species: Homo sapiens
• Sequence 2: NP_001259553.1
• Gene: Flo2 / 32425
• FlyBaseID: FBgn0264078
• Length: 448
• Species: Drosophila melanogaster
• Alignment Length: 443
• Identity: 185/443 - (41%)
• Similarity: 281/443 - (63%)
• Gaps: 30/443 - (6%)

Human     4 TCGPNEAMVVSGFC--RSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVT 66
            |.|||||::|||.|  .:....:.||..:....:..:||:|||.:|||...|.|.|..|||::||
  Fly     6 TTGPNEALIVSGGCCGSTKKRTIVGGWAWAWWLVTDVQRLSLNVMTLNPMCENVETSQGVPLTVT 70

Human    67 GIAQVKI----------------------QGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQR 109
            |:||.||                      ..|..|:|..|.:.||||:..||....|:|||||.|
  Fly    71 GVAQCKIMKSSSYKQTDYHNDEMMNVYYFHHQADELLGTASEQFLGKSVKEIKQTILQTLEGHLR 135

Human   110 AIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQK 174
            ||:..:||||:||||.:|:..|.:||:.|:..|||.::|:|:||::||..||.|||||:||.|::
  Fly   136 AILGTLTVEEVYKDRDQFAALVREVAAPDVGRMGIEILSFTIKDVYDDVQYLASLGKAQTAVVKR 200

Human   175 DARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQ 239
            ||..|.|||.||||||||:.::..:..:|.::.::....|.|:|:||.:|.|:||.:|::.|||:
  Fly   201 DADAGVAEANRDAGIREAECEKSAMDVKYSTDTKIEDNTRMYKLQKANFDQEINTAKAESQLAYE 265

Human   240 LQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQ 304
            ||.||.:|:|..:.:|::||||.:|:.::.||:.|:::||...|:.|||||.::|:.||:|::.|
  Fly   266 LQAAKIRQRIRNEEIQIEVVERRKQIEIESQEVQRKDRELTGTVKLPAEAEAFRLQTLAQAKQCQ 330

Human   305 LIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
            .|..|.|||..:|..|.|||.||....:||||:|..||..::.|.:||.::::||.||::|.|::
  Fly   331 TIEGARAEAERIRKIGSAEAHAIELVGKAEAERMRMKAHVYKQYGDAAIMNIVLESLPKIAAEVA 395

Human   370 GPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNHK 422
            .||...::|.|:.      |...:|.:|..::.:||.|:..||||.:|:|..|
  Fly   396 APLAKTDEIVLIG------GNDNITNDVTRLVAQLPPSINALTGVDLSKVLSK 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FLOT1	NP_005794.1	Flot	4..419	CDD:330594	183/438 (42%)
		SPFH_flotillin	30..175	CDD:259798	72/166 (43%)
Flo2	NP_001259553.1	SPFH_flotillin	34..201	CDD:259798	72/166 (43%)
		PHB	110..281	CDD:214581	82/170 (48%)
		SPFH_like	<286..374	CDD:302763	38/87 (44%)
		Flot	337..>410	CDD:292597	30/78 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2268
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4089
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D340567at33208
OrthoFinder	1	1.000	-	-		FOG0001627
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.770