DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDK6 and msn

DIOPT Version :9

Sequence 1:	NP_001138778.1	Gene:	CDK6 / 1021	HGNCID:	1777	Length:	326	Species:	Homo sapiens
Sequence 2:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster

Alignment Length:	324	Identity:	91/324 - (28%)
Similarity:	148/324 - (45%)	Gaps:	65/324 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR-EVAVLRHLETFEHPNV 76
            :|.:..:|.|.||:|:|.|..|. |:..|:|.:.|...||    ..|: |:.||:...  .|.|:
  Fly    32 FELIEVVGNGTYGQVYKGRHTKT-GQLAAIKVMDVTEDEE----EEIKLEINVLKKYS--NHRNI 89

Human    77 VRLFDV-CTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE-PGVPTETIKDMMFQLLRGLDFLHSH 139
            ...:.. ...|...::.:|.||.|:......|.|.|..: ..:..|.|..:..::||||.:|||:
  Fly    90 ATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSN 154

Human   140 RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT-----SVVVTLWYRAPEVLL-----QS 194
            :|:|||:|.||:|:|.:.::||.|||:    |.|:..|     :.:.|.::.||||:.     .:
  Fly   155 KVIHRDIKGQNVLLTDNAEVKLVDFGV----SAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDA 215

Human   195 SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSA 259
            :|....||||:|....||...:|..   .|:..:..:..:         ||: :.||    .||.
  Fly   216 TYDNRSDLWSLGITALEMAESQPPL---CDLHPMRALFLI---------PRN-SPPR----LKSK 263

Human   260 QPIEKFVTDIDE-LGKDLLLKCLTFNPAKRISAYSALSHPYFQD--------------LERCKE 308
            :..:||...||. |.||...:..|.|         .|.|.:.:|              ::|||:
  Fly   264 KWSKKFHGFIDTVLVKDYHQRPYTEN---------LLKHGFIKDQPTDRQVRIQLKDHIDRCKK 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDK6	NP_001138778.1	STKc_CDK6	11..300	CDD:270846	87/300 (29%)
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	87/300 (29%)
		S_TKc	32..296	CDD:214567	87/300 (29%)
		CNH	1183..1484	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910