Protein Alignment CDK6 and Eip63E

DIOPT Version :10

• Sequence 1: NP_001250.1
• Gene: CDK6 / 1021
• HGNCID: 1777
• Length: 326
• Species: Homo sapiens
• Sequence 2: NP_001261373.1
• Gene: Eip63E / 38433
• FlyBaseID: FBgn0005640
• Length: 538
• Species: Drosophila melanogaster
• Alignment Length: 310
• Identity: 129/310 - (41%)
• Similarity: 175/310 - (56%)
• Gaps: 33/310 - (10%)

Human    11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75
            :.|..:..:|||:|..|:|........| ||||.:|:|. |||.|.:.|||.::|:.|   :|.|
  Fly   203 EAYVKLEPLGEGSYATVYKGFSKLTYQR-VALKEIRLQE-EEGAPFTAIREASLLKEL---KHSN 262

Human    76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHR 140
            :|.|.|:...    ||| ||.|||:|:.||:.|::|.| .|:....::..:|||||||.:.|..|
  Fly   263 IVTLHDIVHT----RET-LTFVFEYVNTDLSQYMEKHP-GGLDHRNVRLFLFQLLRGLSYCHKRR 321

Human   141 VVHRDLKPQNILVTSSGQIKLADFGLAR-------IYSFQMALTSVVVTLWYRAPEVLLQSS-YA 197
            |:|||:||||:|::..|::|||||||||       .||.:      |||||||.|:|||.|: |:
  Fly   322 VLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHE------VVTLWYRPPDVLLGSTEYS 380

Human   198 TPVDLWSVGCIFAEMFRRKPLFRGSSDV-DQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQP 261
            |.:|:|.|||||.||....|.|.|..|. |||.||..::|.|.|:.||.....|....|......
  Fly   381 TSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYR 445

Human   262 IEKF------VTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305
            ..|.      :.||.| |:.:....|..||.:|:.|..||.||||..|.:
  Fly   446 PRKLGHNFPRLYDIIE-GETIANGFLQLNPEQRLGADDALQHPYFAQLPK 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK6	NP_001250.1	STKc_CDK6	11..300	CDD:270846	126/303 (42%)
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	126/302 (42%)