Protein Alignment CDK6 and CG42366

DIOPT Version :10

• Sequence 1: NP_001250.1
• Gene: CDK6 / 1021
• HGNCID: 1777
• Length: 326
• Species: Homo sapiens
• Sequence 2: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Alignment Length: 301
• Identity: 119/301 - (39%)
• Similarity: 175/301 - (58%)
• Gaps: 21/301 - (6%)

Human    12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV--RVQTGEEGMPLSTIREVAVLRHLETFEHP 74
            :|..:.::|:|.||.|...: .|:.|..||:||:  :..:.||.|   .:|||..|:.|   .||
  Fly     3 RYITLTQLGDGTYGTVVLGQ-RKDTGEKVAIKRMKRKYYSWEEAM---NLREVKSLKKL---SHP 60

Human    75 NVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSH 139
            |:|:|.:|...:.|     |..|||::.::|...: |..:..:|...:|.::||:|.||.|:|.|
  Fly    61 NIVKLKEVIRENDT-----LYFVFEYMKENLYQMI-KDRDTHLPEPELKSILFQVLTGLAFMHRH 119

Human   140 RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS-SYATPVDLW 203
            ...||||||:|:|.:....||:|||||||....:...|..|.|.|||||||||.| :|.:.:|||
  Fly   120 GFFHRDLKPENLLCSGPDLIKIADFGLAREIRSRPPFTDYVSTRWYRAPEVLLHSTNYGSTIDLW 184

Human   204 SVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ----PIEK 264
            ::|||.||::..:|||.|||:||||.||..|:|.|.::|||....| ....|.:...    |:..
  Fly   185 AMGCIMAELYTFRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRL-ASMIHFRYPDCIKVPLSS 248

Human   265 FVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305
            .|:...:.|.|||...|.::|.||.:|..:|.:|||..|:|
  Fly   249 VVSRCSQNGLDLLEDMLAYDPDKRPTAQQSLKYPYFHALKR 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK6	NP_001250.1	STKc_CDK6	11..300	CDD:270846	115/294 (39%)
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	115/293 (39%)