DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PATJ and GUK1

DIOPT Version :9

Sequence 1:	XP_011538764.1	Gene:	PATJ / 10207	HGNCID:	28881	Length:	1937	Species:	Homo sapiens
Sequence 2:	NP_010742.1	Gene:	GUK1 / 852065	SGDID:	S000002862	Length:	187	Species:	Saccharomyces cerevisiae

Alignment Length:	142	Identity:	30/142 - (21%)
Similarity:	50/142 - (35%)	Gaps:	47/142 - (33%)

- Green bases have known domain annotations that are detailed below.

Human  1093 LKNGEELK---------GIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA 1148
            :||.|.::         |..:..|.:.|.:|||..|          .:|:|..   ::|:||...
Yeast    63 IKNNEFIEWAQFSGNYYGSTVASVKQVSKSGKTCIL----------DIDMQGV---KSVKAIPEL 114

Human  1149 GNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPM-------------- 1199
            ....:||..         |:|.:...::.| :..:|:|...||...|...:
Yeast   115 NARFLFIAP---------PSVEDLKKRLEG-RGTETEESINKRLSAAQAELAYAETGAHDKVIVN 169

Human  1200 -KLPPPYKALTD 1210
             .|...||.|.|
Yeast   170 DDLDKAYKELKD 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PATJ	XP_011538764.1	L27_2	8..65	CDD:117611
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	246..325	CDD:238492
		PDZ_signaling	366..450	CDD:238492
		PDZ_signaling	570..634	CDD:238492
		PDZ	683..772	CDD:214570
		PDZ_signaling	1066..1157	CDD:238492	17/72 (24%)
		PDZ	1236..1321	CDD:214570
		PDZ	1459..1574	CDD:214570
		PDZ_signaling	1586..1666	CDD:238492
		PDZ_signaling	1729..1814	CDD:238492
		PDZ_signaling	1852..1936	CDD:238492
GUK1	NP_010742.1	guanyl_kin	3..185	CDD:213788	30/142 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900