DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PATJ and Patj

DIOPT Version :9

Sequence 1:	XP_011538764.1	Gene:	PATJ / 10207	HGNCID:	28881	Length:	1937	Species:	Homo sapiens
Sequence 2:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster

Alignment Length:	962	Identity:	288/962 - (29%)
Similarity:	407/962 - (42%)	Gaps:	307/962 - (31%)

- Green bases have known domain annotations that are detailed below.

Human     6 ATDKLQVLQVLDRLKMKLQEKGDTSQN----EKLSMFYETLKSPLFNQILTLQQSIKQLKGQLNH 66
            :.|....||.::.:|..:.|..|....    |.||.....|:.|:|..|:.:|.|:.:|..||..
  Fly     4 SADISSALQQIEAVKKGIDESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLAQ 68

Human    67 IPSDCSANFDFSRKGLLVFTDGSITNGNV------HRPSNNSTVSGLFPWTPKLGNEDFNSVIQQ 125
            .||....:||....|.||.   |:..|.|      .|.|::|..:   |.:|
  Fly    69 HPSMLPNDFDIDVAGNLVL---SLNGGEVMYDFDEQRSSSHSHSA---PGSP------------- 114

Human   126 MAQGRQIEYIDIERPSTGGLGFSVVALRSQN---LGKVDIFVKDVQPGSVADRDQRLKENDQILA 187
                          ..:||:| .....:|||   .|..|::..|
  Fly   115 --------------DKSGGVG-EEPRPQSQNSKGAGVADLYATD--------------------- 143

Human   188 INHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELI 252
                                                                   :..::.:||:
  Fly   144 -------------------------------------------------------YAQIQAIELV 153

Human   253 NDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCG 317
            |||:||||||:|.:.|||:|:||:|||:||:||||::|||||:||..|:..|.|||||.|||..|
  Fly   154 NDGTGLGFGIIGARNSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSG 218

Human   318 NSVRMLVARDPAGDISVTP-----PAPAALPVAL---PTVASK-----------GPGSDSSLFET 363
            ..||::||| |......||     |..|.:|..:   |....:           |..|.:|..:|
  Fly   219 THVRLVVAR-PVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQT 282

Human   364 Y------------------NVEL---------------VRKDGQSLGIRIVGYVGTSHTGEASGI 395
            .                  |::|               ::||...|||.|.|||  ....|.|||
  Fly   283 TTEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGITIAGYV--CEKEELSGI 345

Human   396 YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVR--------- 451
            :|||:.|||||..:|.|:|||:|:.|||.::||::||..||:|:.:||||:|.|.|
  Fly   346 FVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQ 410

Human   452 ----------------------------RKTSSSTSPLEPPSDRGTVVEPLKPPALFLT------ 482
                                        ..|||:|:.......|....|.|..|..|:|
  Fly   411 LQQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTPSRSITRELEEEALPAPEAFMTTPPSVT 475

Human   483 ----------GA----VETETNVDGEDEEIKERIDTL------KNDNIQALEKLEKVP---DSPE 524
                      ||    |....::||..:.|...:..|      ||..:....|....|   |..|
  Fly   476 TMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSGVITRHKYYTDPELSDDAE 540

Human   525 NELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVE--VDSFDG-----HHY 582
            .|:..:|:.::|.|.||:|          |:::|::    :..|.:.:|  ||...|     |||
  Fly   541 TEIIRKWQKIVGSDVEVIV----------AQIKKFA----VGGLGISLEGTVDVEGGREVRPHHY 591

Human   583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL------FD 641
            |.||:..|||...|:|:..||||||||.:|.|.:..|.|:.|||:|....:||.|..      |.
  Fly   592 IRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFS 656

Human   642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDD---------DGE--------------------- 676
            |:.........|..||.|:    ..|..:.|.         ||:
  Fly   657 DDTLKKLSNNFENLLPATD----RLVKAKSDGSLATAGSVADGDSVAAAAASFSKLKSRSLEPLT 717

Human   677 -LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSV 740
             ||:||.:.:|:||||..:|||||||||||||||..::|||||||..|||:..|.|:|||||:.|
  Fly   718 GLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRLLFV 782

Human   741 NEYCLDNTSLAEAVEILKAVPPGLVHLGICKPL-VEDNEEESCYILHSSSNE 791
            |...|:|.||.:||:.||....|:|.:|:.||| :.||..::|....::|.|
  Fly   783 NSINLENASLDQAVQALKGASKGVVRIGVAKPLPMTDNSLKACSNASTTSEE 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PATJ	XP_011538764.1	L27_2	8..65	CDD:117611	17/60 (28%)
		PDZ_signaling	135..218	CDD:238492	9/85 (11%)
		PDZ_signaling	246..325	CDD:238492	47/78 (60%)
		PDZ_signaling	366..450	CDD:238492	43/98 (44%)
		PDZ_signaling	570..634	CDD:238492	31/70 (44%)
		PDZ	683..772	CDD:214570	50/88 (57%)
		PDZ_signaling	1066..1157	CDD:238492
		PDZ	1236..1321	CDD:214570
		PDZ	1459..1574	CDD:214570
		PDZ_signaling	1586..1666	CDD:238492
		PDZ_signaling	1729..1814	CDD:238492
		PDZ_signaling	1852..1936	CDD:238492
Patj	NP_477342.1	L27	12..70	CDD:295425	16/57 (28%)
		PDZ_signaling	154..226	CDD:238492	45/71 (63%)
		PDZ_signaling	318..400	CDD:238492	42/83 (51%)
		PDZ_signaling	557..643	CDD:238492	36/99 (36%)
		PDZ_signaling	726..807	CDD:238492	48/80 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7199
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003499
OrthoInspector	1	1.000	-	-		otm40813
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4712
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.800