DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PATJ and mpz-1

DIOPT Version :9

Sequence 1:XP_011538764.1 Gene:PATJ / 10207 HGNCID:28881 Length:1937 Species:Homo sapiens
Sequence 2:NP_001364655.1 Gene:mpz-1 / 174657 WormBaseID:WBGene00003404 Length:2422 Species:Caenorhabditis elegans


Alignment Length:2684 Identity:632/2684 - (23%)
Similarity:907/2684 - (33%) Gaps:1169/2684 - (43%)


- Green bases have known domain annotations that are detailed below.


Human     7 TDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQI------------------LTL 53
            :::.::.:||..||.: :|.||.  .|.:......||.|||.|:                  ...
 Worm    34 SEEERIREVLRELKSR-KEGGDV--KEDIERIERILKDPLFKQLSHQPTSSPETFKSDNRRNSAA 95

Human    54 QQSIKQLKGQLNHIPSDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNED 118
            ::.:.::..::.  .|:...|...::|.|.::.|..:.:..|......|  |.|....||     
 Worm    96 EKRVVEISKRIE--SSEIRKNLKQNQKLLFIYVDAKLVDPVVLETKEKS--SRLLVVGPK----- 151

Human   119 FNSVIQQMAQGRQIEYIDIERPSTGGL--GFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKE 181
                             |::..|||.|  |..|||:.:.....|     ...|.|....|     
 Worm   152 -----------------DVKNRSTGKLRIGDCVVAIDASGGSSV-----PSAPSSTVSSD----- 189

Human   182 NDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVC---- 242
                                      .|.|:.....||..:|.::...|..      ||.|    
 Worm   190 --------------------------DTKGAAATTTARFAIHNQTIGKSEF------ETACHKSI 222

Human   243 ----------------------WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDG 285
                                  |..||.:.|..:..|||||||||.::||||:||:||..||:||
 Worm   223 SAKQHLVVGVIREATPMVLSGDWTQVEVIHLNTETGGLGFGIVGGTSTGVVVKTILPGSPADKDG 287

Human   286 RLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD----------------------- 327
            |||.|||||:||..|..||:|:|||.:||:...:|.|:|.|.                       
 Worm   288 RLQPGDHILQIGNINSHGMSSQQVATILRHQHPTVDMIVGRPIAYADKPIDTPECFTLATKAALC 352

Human   328 ----------------PAGDISVTP----PAPAALPV----------ALPTVASKGP-------- 354
                            |:...:.||    |:.:.:|:          ..||.:.:.|        
 Worm   353 ATTLEEALQRQMATSVPSTTANQTPNTLSPSISCVPIEEEKEEKEPEPEPTTSKEQPIKITTYLP 417

Human   355 ----------------------------------------------------------------- 354
                                                                             
 Worm   418 DTIDIRKPCDCAPNYNRRDKRKSSCDDGEHGDGDGGGGCKKTKEDHQEEENEIDSKDELGEMVRS 482

Human   355 ------------------------------------------------GSDSSLFETYNVELVRK 371
                                                            ..:|:.||..:|.|.|.
 Worm   483 PTVETGQSDENSVVTSVSRSSKRNSNSITSRISLKSLQEMALTVFLRENWESTKFELIDVALHRD 547

Human   372 DGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVE 436
            ....|||.:.|||....  |..||:|||::|.|||..:|.|:|:|.|:.|:|..::..::.|.|.
 Worm   548 PALGLGITVAGYVHKKE--EIGGIFVKSLVPRSAASSSGVIKVHDLILEVNGTTLEHMSHADSVR 610

Human   437 VLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKER 501
            .|..:|..|.|.|||       .||..|          :...|.:....||||.|          
 Worm   611 TLVKSGDQVKLKLVR-------FPLSSP----------QAQCLKMLQQQETETQV---------- 648

Human   502 IDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATL--DTQIADDAELQKYSKLLP 564
            ||.          ||.. ||     |...|::.:|.|.|::.|.:  |.|..|..          
 Worm   649 IDV----------KLSN-PD-----LVKEWKSRIGDDIEIIAAVVKPDRQSVDGG---------- 687

Human   565 IHTLRLGVE----VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSR--- 617
                 ||:.    ||..:|     ||||.||...|||....:||..||||:||...|||:|.   
 Worm   688 -----LGISLEGTVDVLNGAQLCPHHYIESIRQDGPVAKTKVLQAGDELLQVNHSPLYGESHVTV 747

Human   618 REAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLP----------ETEVDHNMDVN---- 668
            |:|::.......|.||:..||  .....|.||...|..||          ||.|....|::    
 Worm   748 RQALTRAVHSGAPVTLIVARR--SQHLHVFEPTTYEKQLPLSFPFLAANQETVVKAKSDIDLTST 810

Human   669 ------------------TEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIV 715
                              :.|:..| ||:|:....::.|.||.:||||||:||:||.....||||
 Worm   811 RAETTHLLQRVSRRLRSKSLENFHG-LAVWNCVPLVIHLCKDSRGLGFSIVDYKDPTHRDESVIV 874

Human   716 IRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVED---- 776
            ::|||..|||:..|.::|||||:.||.:.|.|:||..||.:|||...|.|.||:.||:..|    
 Worm   875 VQSLVPGGVAQADGRVVPGDRLLFVNNHDLSNSSLERAVAVLKAARMGPVRLGLAKPIPVDQSQF 939

Human   777 -------------------------------NEEESCYI--------LH--------------SS 788
                                           :.:|:.:|        ||              |.
 Worm   940 TSHSPLCSRSERLLARGRSPRGRRRYTSGTTSSQETVWIGTAEQYRKLHPQGYYPSRSPSAARSE 1004

Human   789 SNEDKTEFS-------------------------------------------------------- 797
            .:.:.:|||                                                        
 Worm  1005 RSIEGSEFSMTSWSPCSTRSVSPCGSPISLRGSWAYDVVFLPTHLERTVKLQKGALPLGAVLDGD 1069

Human   798 ---------------------------------------------------------GTIHDI-- 803
                                                                     ||..::  
 Worm  1070 KDKGVNGCVVKSICGKKAVALDGRIQVGDFITKINTESLRNVTNSQARAILKRTNLVGTFCNVTY 1134

Human   804 ------------------NSSLILE--APKGF----------RDEPYFKEELVDE----PFL--- 831
                              :||.|:.  :||.|          |.|...|.|:.|:    |.:   
 Worm  1135 ITSADAKTWKERFQRPSESSSPIINRLSPKVFPKFYRSPFMQRQESQSKTEMTDDETEAPSIMTD 1199

Human   832 ---------DL----GKSFHSQQK---EIEQSKEAWEMHEFLTPRLQE--MDEEREILV------ 872
                     ||    .:|.|.:|:   .:.:..:..|:.:|:...::|  .|...|:.|      
 Worm  1200 SMSEHIKTFDLAEGSSRSHHDEQEVRNRMSRLIDGVEVDDFVNLIIKEAITDATIELRVLHKTKD 1264

Human   873 --------DEEYELYQDPSPSMELY---PLSHIQEATPVP------------SVNELHFG--TQW 912
                    :|..|....|.|..|:.   |.|.:....|.|            |..|.|.|  |..
 Worm  1265 WSNCNHKREERLESPPLPPPPPEVLSSPPKSPVASVQPTPRDLEEVLTRSTASSLEYHSGQRTSQ 1329

Human   913 LH-----------------DNEPSE-------SQEARTGRTVYSQEAQPYGYCPENVMKENFVME 953
            ||                 :|:.||       |.....|.....:|.:......|||.:......
 Worm  1330 LHILSTEEEVLQATPPSSPENKSSEVPPSISPSGIKLAGEVTAPEEIEVVKEQAENVDRAETAAT 1394

Human   954 ----SLPSVPSTE--GNSQQGRFDDLENLNSLAKTSLDLGMIPNDVQGPSLLIDLPVVAQRREQE 1012
                ...|.|:.|  |||:    ||.....|:::.|:.|                          
 Worm  1395 GAEVEATSTPTAEAIGNSK----DDESTTTSISQQSVGL-------------------------- 1429

Human  1013 DLPLYQHQA---TRVISKASAYTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFRE 1074
                 |.||   |.|.|..|..|....|..:       |..:.:..:.....:||..|.|.:.||
 Worm  1430 -----QTQALNSTEVNSNMSRVTSRTPSTGS-------ESLQNQARQLVRSKYWGEARTVTLVRE 1482

Human  1075 PNVSLGISIVGGQTVIKRL----KNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135
            ||.|.|||||||:..:.:.    ..|..:.|||||.||.:||||::..:..||:::.|:.|||::
 Worm  1483 PNKSFGISIVGGRVEVSQKGGLPGTGNTVCGIFIKSVLPNSPAGRSGQMNMGDRVISVNDVDLRD 1547

Human  1136 ASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKA-NKITGN---QNQDTQEK--------- 1187
            |:|.:||.|||||.|||.|::|||.:..:   |:.|.| |...|:   :|...:|:         
 Worm  1548 ATHEQAVNAIKNASNPVRFVLQSLHTNQQ---NMINSASNSTVGSVRFENAKPEEELPPTALVTP 1609

Human  1188 -----KEKRQGTAPPPMKLPPPYKALTD----DSDENEEE------------------------- 1218
                 ......|:.|.|..|||..:.|.    :|:..|||                         
 Worm  1610 LKPMISSSGSSTSKPAMNFPPPSISTTTTTSMESESKEEEATSSSPDIQRENTVKRRSMDVEREQ 1674

Human  1219 ----------------------------------------------------------------- 1218
                                                                             
 Worm  1675 PEANPVEETSIVKEKTPPRKISAKSNSSQKESNDRKEIKKQKSVEREMSVESKKSVRSIKKHRQE 1739

Human  1219 --------------------------------------------DA------------------- 1220
                                                        ||                   
 Worm  1740 STIIKKSPSNETAPLIVSDVSSSETHEDEPQAMSPSTSFDTRDADAMRALGIDDDSAAFQIKNDG 1804

Human  1221 -------FTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAAD 1278
                   :|..||.::|....|||.::..|:...|||:||||||||.:.::|||.:.|..|.|  
 Worm  1805 EEPSKFFYTAGKIERKYDSDGGELVLVACERPDGGLGISLAGNKDRDKQNVFVVNVRPSCPLA-- 1867

Human  1279 GRMRIGDELLEINNQILYGRSHQNASAIIKTA---PSKVKLVFIRNEDAVNQMAV--------TP 1332
              :|.||||||||.::|...||..|||:::..   ...:::|..|...|:|:.||        ..
 Worm  1868 --IRPGDELLEINGRLLNKISHVAASAVVRECCDQHQNIEIVLRRRNGALNECAVRSDTITSSQS 1930

Human  1333 FPVPSSSPSSI--EDQSGTEPISSEEDGSVEVGIKQLPESESFKLEDMSQVIGQGMVADQQKALE 1395
            .|.|.:|||::  .:...|.|              |:|.:.            :|:         
 Worm  1931 LPSPPTSPSTLAPSESKSTAP--------------QMPTTT------------EGI--------- 1960

Human  1396 YPPDNAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQE 1460
               :||..  .|::...|.|||.:.                               |..|..|:|
 Worm  1961 ---ENAAP--NQEELSRKKSFSQER-------------------------------TQAIENGRE 1989

Human  1461 MIIEISKGRSGLGLSIVGGKDTPLFWRLGSPRAWSQHLVRAFMLHHPVTEVEGQNAIVIHEVYEE 1525
            .:|||.|...|||||||||.||.|                              ..:||||||.:
 Worm  1990 TMIEIDKDGKGLGLSIVGGADTVL------------------------------GTVVIHEVYSD 2024

Human  1526 GAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD---EAHYRDEENL-EI 1586
            ||||.||||..|||:|||||..||..:|:::|..||:||.||||::|||   :....|...: .|
 Worm  2025 GAAAHDGRLKPGDQVLEVNGTSLRGVTHDQSIAYLRRTPPKVRLLIYRDVNLQLSLLDPTQIYNI 2089

Human  1587 FPVDLQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETV 1651
            |.:||.||.|||||:||||::|..||::|:|||||.|:.||||:.|||||.|||:|:|...||.|
 Worm  2090 FEIDLVKKTGRGLGISIVGRKNEPGVYVSEIVKGGLAESDGRLMTGDQILEVNGKDVRGCMQEDV 2154

Human  1652 ATILKCAQGLVQLEIGRLR---------------AGSWTSARTTSQN------------SQGSQQ 1689
            |.:||...|.|.|::||.:               |.|.|:.|||..|            |..:..
 Worm  2155 AAMLKTITGKVHLKLGRWKITETANRVHAATQALAKSATTPRTTENNNDPVRPVAVAVSSPAATP 2219

Human  1690 SAHSSC------------------------------------HPSFAPVITGL--------QNLV 1710
            |..:|.                                    .|...|:||..        |...
 Worm  2220 STSASVTVTSAPATSVPEPNVVVEPIPGPTSAREERNDVPPPAPPMRPIITHTSPEGCETQQEPA 2284

Human  1711 GTKRVSDPSQKNSGTDM-------EPRT-------------------------------VEINRE 1737
            |...|::  :.:||.|.       :|||                               ||:.:.
 Worm  2285 GLSPVTE--EPSSGCDFMSVQEEEQPRTPTTTTSSSNNNNSLAIDIIHDLKEEGSDTLLVELKKV 2347

Human  1738 LSDALGISIA-GGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPL-DGLSHADVVN 1800
            :...||:.|. ..||       :.:..:|....||  :||||||||:::|..|: |.||   .|.
 Worm  2348 VDQQLGMGIGKRSRG-------ILVTSLQPGSAAA--EKLKVGDRILAVNALPVSDQLS---AVT 2400

Human  1801 LLKNAYGRIILQVVADTNI 1819
            .:|.:..|:.||:....:|
 Worm  2401 FVKASGQRLYLQIARPHSI 2419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PATJXP_011538764.1 L27_2 8..65 CDD:117611 14/74 (19%)
PDZ_signaling 135..218 CDD:238492 15/84 (18%)
PDZ_signaling 246..325 CDD:238492 45/78 (58%)
PDZ_signaling 366..450 CDD:238492 32/83 (39%)
PDZ_signaling 570..634 CDD:238492 30/75 (40%)
PDZ 683..772 CDD:214570 44/88 (50%)
PDZ_signaling 1066..1157 CDD:238492 45/94 (48%)
PDZ 1236..1321 CDD:214570 36/87 (41%)
PDZ 1459..1574 CDD:214570 52/114 (46%)
PDZ_signaling 1586..1666 CDD:238492 48/79 (61%)
PDZ_signaling 1729..1814 CDD:238492 31/117 (26%)
PDZ_signaling 1852..1936 CDD:238492
mpz-1NP_001364655.1 PDZ_signaling <271..326 CDD:238492 33/54 (61%)
PDZ_signaling 539..624 CDD:238492 32/86 (37%)
PDZ_signaling 685..766 CDD:238492 32/95 (34%)
PDZ_signaling 843..926 CDD:238492 42/82 (51%)
PDZ 1050..1124 CDD:214570 0/73 (0%)
PDZ_signaling 1475..1569 CDD:238492 45/93 (48%)
PDZ 1827..1912 CDD:214570 37/88 (42%)
PDZ 1988..2073 CDD:214570 52/114 (46%)
PDZ_signaling 2089..2169 CDD:238492 48/79 (61%)
PDZ_signaling 2341..2414 CDD:238492 28/84 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 101 1.000 Domainoid score I4795
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 585 1.000 Inparanoid score I601
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51355
OrthoDB 1 1.010 - - D1419918at2759
OrthoFinder 1 1.000 - - FOG0003499
OrthoInspector 1 1.000 - - otm16011
orthoMCL 1 0.900 - - OOG6_103252
Panther 1 1.100 - - O PTHR19964
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4712
SonicParanoid 1 1.000 - - X1763
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1212.010

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