DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PATJ and patj

DIOPT Version :9

Sequence 1:	XP_011538764.1	Gene:	PATJ / 10207	HGNCID:	28881	Length:	1937	Species:	Homo sapiens
Sequence 2:	XP_002931635.3	Gene:	patj / 100036704	XenbaseID:	XB-GENE-998168	Length:	1829	Species:	Xenopus tropicalis

Alignment Length:	1980	Identity:	1148/1980 - (57%)
Similarity:	1383/1980 - (69%)	Gaps:	194/1980 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPENPAT-----DKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQL 60
            ||||..|     ||.|||.:.:||:.||::|||.|.:||:.:..:||||||||||||:|||||||
Frog     1 MPENMNTGTVTVDKAQVLLIAERLQKKLKDKGDLSHHEKMCILRDTLKSPLFNQILTVQQSIKQL 65

Human    61 KGQLNHIPSDCSANFDFSRKGLLVF-TDGSITNGNVHRPSNNST-----VSGLFPWTPKLGNEDF 119
            |.|||.:|:|.||.|||::|||||| .|.|...||    .|||.     ||...|.......::|
Frog    66 KEQLNRMPADRSAEFDFTKKGLLVFEADSSAHFGN----KNNSLSFDNFVSSQLPLVSPYSEDEF 126

Human   120 NSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQ 184
            |..:||||:||||||||||:||.||||||||||::..:|:..:|:::|||||:||:|.|||||||
Frog   127 NRKLQQMAEGRQIEYIDIEKPSVGGLGFSVVALKNPTVGEAGVFIREVQPGSIADKDGRLKENDQ 191

Human   185 ILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEV 249
            |||||:.|||.::|||::||:|||::||:||:||:.||.......|:    .|...:.|||||::
Frog   192 ILAINYIPLDMSVSHQESIAMLQQSSGSIRLVVAKAPVLNNFQALSN----NLDNQIQWGHVEDI 252

Human   250 ELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLR 314
            |||||||||||||||||.|||:|||||.||||||||||:||||||:||.||||||.|:|||||||
Frog   253 ELINDGSGLGFGIVGGKASGVIVRTIVSGGLADRDGRLKTGDHILQIGDTNVQGMASDQVAQVLR 317

Human   315 NCGNSVRMLVARDPAGDISVTPPAPAALPV-ALPTVASKGPGSDSSLFETYNVELVRKDGQSLGI 378
            ||||||:|:|||||....| .|||||.||| |||....||...::.  ..|:::|.:|:||||||
Frog   318 NCGNSVKMVVARDPIERPS-KPPAPATLPVGALPPKDVKGDNENTD--NVYDIKLTKKEGQSLGI 379

Human   379 RIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQ 443
            .:|||.| :..|.:||||||||||||||..:|.|||.|:|:||||||||.::|.|||..|||.||
Frog   380 TVVGYTG-AFNGGSSGIYVKSIIPGSAADQSGCIQVQDRIIAVDGVNIQDYSNQDVVAALRNTGQ 443

Human   444 VVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKND 508
            .|||||.|.|........|....|.....|..||.        .|.|....:||.:|::|..||:
Frog   444 TVHLTLSRSKELLELVATERSLVRAVPGLPSDPPV--------PEINKSSANEENQEQVDNYKNE 500

Human   509 NIQALEKLEKVPDSPENE-LKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
            .|..       ..||:.. |||:||..|||||.|||..||.:|.||||||||||||||||:||||
Frog   501 MITG-------SLSPQTSILKSKWEQRLGPDYLVMVVNLDPKIDDDAELQKYSKLLPIHTMRLGV 558

Human   573 EVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
            |:||||||||||||...|||..||:.|||||||||||:|||||||||||||||||||||||||||
Frog   559 ELDSFDGHHYISSIAPEGPVAKLGIFQPEDELLEVNGVQLYGKSRREAVSFLKEVPPPFTLVCCR 623

Human   638 RLFDD--EASVDEPRRTET-----SLPETE-----VDHNMDVNTE----------EDDDGELALW 680
            |:.||  |..||.|...:|     .:|.||     |..:...|:|          |:||||||:|
Frog   624 RMVDDENETFVDVPNTLDTKDNKNEIPVTEEEDQTVQSSERSNSEYAQPLENLVTEEDDGELAMW 688

Human   681 SPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCL 745
            |.|||:|||.||..|||||||||||||||.|:|:||:|||::||||.||.:|||||||.||:..:
Frog   689 SSEVKVVELEKDSGGLGFSILDYQDPLDPARTVLVIQSLVSNGVAETSGQILPGDRLVFVNDNYM 753

Human   746 DNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHDINSSLILE 810
            ||.||.:||:||.:||||...||||||||...:||.....:....||.|:.:.|     .|:||:
Frog   754 DNASLEDAVQILTSVPPGRTRLGICKPLVGSIKEEKDIYTNLEELEDNTDSTAT-----DSVILD 813

Human   811 APKGFRDEPYF---KEELVDEPFLDLGKSFHSQQKEIEQSKEAWEMHEFLTPRLQEMDEEREILV 872
            ....:::..:.   :|||||||.|::||.|:.:..:....:|:|||.|     |:....|||:||
Frog   814 VFHKYKEGVFIQDEQEELVDEPSLNMGKQFNIEHNKTGSLQESWEMQE-----LEGYGGEREMLV 873

Human   873 DEEYELYQDPSPSMELYPLSHIQEATPVPSVNELHFGTQWLHDNEPSESQEARTGRTVYSQEAQP 937
            ||||...::.|...:.|.|.  .|...:|...:..:...|:.|....      :|...:..|.|.
Frog   874 DEEYTEQENFSEDSDHYFLQ--CEGIAMPPGKDSGYSQPWMEDIHMD------SGAMKFKLETQE 930

Human   938 YGYCPENVMKENFVMESLPSVPSTEGNSQQGRFDDLENLNSLAKTSLDLGMIPNDVQGPSLLIDL 1002
            ...|.:                           |||:       |.:..|.: ..::.|.::.|.
Frog   931 TMLCHQ---------------------------DDLQ-------TGVSQGTV-YSLKEPGIVFDP 960

Human  1003 PVVAQRREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPR 1067
            ..:||::::|.:..|    ||:|.:.:....:.:|.      |||||||||||||||||||||||
Frog   961 DAIAQQKDREMMEDY----TRIIHQKTQRNQLGASN------ELPEREEGEGEETPNFSHWGPPR 1015

Human  1068 IVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVD 1132
            ||||::||.|||||||||||::||||||||||||||||||||:||||||||||||||||||||||
Frog  1016 IVEIWKEPQVSLGISIVGGQSIIKRLKNGEELKGIFIKQVLENSPAGKTNALKTGDKILEVSGVD 1080

Human  1133 LQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQ-GTAP 1196
            |:||:|.|||.||||:|||||||:||||.|||::...:.|.:|........|.:...... ...|
Frog  1081 LKNATHEEAVNAIKNSGNPVVFIIQSLSPTPRLMTAGNTKTSKYDKASTDSTVKTVSPVPFSGGP 1145

Human  1197 PPMKLPPPYKALTDDS--DENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDR 1259
            ||||||||||..:|..  :...|||  :|.|||||||||.|:|||||||||||||||||||||||
Frog  1146 PPMKLPPPYKESSDSHPLEMKAEED--SDDKIRQRYADLLGDLHIIELEKDKNGLGLSLAGNKDR 1208

Human  1260 SRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDA 1324
            ||||||||.|||:|||..|||:.:|||||||||||:||:||||||||||.|||.:|||||||:||
Frog  1209 SRMSIFVVAINPDGPAGQDGRIHVGDELLEINNQIIYGKSHQNASAIIKGAPSTLKLVFIRNKDA 1273

Human  1325 VNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLEDMSQVIGQGMVAD 1389
            |.||||.|.|:|.||            ::.||...:.|..|  .|..|||     :::.....::
Frog  1274 VQQMAVNPDPLPESS------------LTDEEHCGLAVSGK--GEETSFK-----EIMASVTESE 1319

Human  1390 QQKALEYPPDNAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPL-SVDPATC 1453
            .:.|::       :|.|..|..||:|..||::.|....||...::|.:.|....:|| |.|||||
Frog  1320 AKPAID-------NQQKHSKSDTKISPDSQDVSLTSVPSYLPAESDISNYRNMPSPLPSFDPATC 1377

Human  1454 PIVPGQEMIIEISKGRSGLGLSIVGGKDTPLFWRLGSPRAWSQHLVRAFMLHHPVTEVEGQNAIV 1518
            ||:|||||.|||||||||||||||||.||||                              .|||
Frog  1378 PIIPGQEMTIEISKGRSGLGLSIVGGNDTPL------------------------------EAIV 1412

Human  1519 IHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEEN 1583
            ||||||||||||||||||||||||||||||||:|||:||||||||||||:|.||||||.|:||||
Frog  1413 IHEVYEEGAAARDGRLWAGDQILEVNGVDLRNASHEDAITALRQTPQKVQLTVYRDEAQYKDEEN 1477

Human  1584 LEIFPVDLQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 1648
            |:||.|:|||||||||||||||||.||||||||||||||||:||||:|||||:||||:|||||||
Frog  1478 LDIFHVELQKKAGRGLGLSIVGKRTGSGVFISDIVKGGAADIDGRLMQGDQIMSVNGDDMRNASQ 1542

Human  1649 ETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTK 1713
            |.|||:||||||||.|||||||.|||.:::.|.:.||.:|.|:|....||..|||:.:|:...:|
Frog  1543 EIVATVLKCAQGLVHLEIGRLRVGSWLASKKTFEASQINQMSSHGVLPPSLTPVISSMQDYASSK 1607

Human  1714 RVS-DPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLK 1777
            :.| |.||::||||:|||||||||...||||||||||:|||||||||||||||||||||||.|||
Frog  1608 KSSADSSQRHSGTDLEPRTVEINRGPYDALGISIAGGKGSPLGDIPVFIAMIQASGVAARTHKLK 1672

Human  1778 VGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHLGSPTAEH 1842
            ||||:||||.||:||||||:|||:||:|:|.|:|||||||||||||:|||:||.|..:.|   ||
Frog  1673 VGDRLVSINQQPVDGLSHAEVVNILKHAFGTIVLQVVADTNISAIASQLESMSLGQGVSS---EH 1734

Human  1843 HPEDTETPPPKIITLEKGSEGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAADDGRLKRGDQILAV 1907
            ..||.|:|.||||.||||.:|||||||||||||.|||||||||:|:|||||.|||||||||||:|
Frog  1735 QVEDGESPVPKIIHLEKGGDGLGFSIVGGYGSPQGDLPIYVKTIFSKGAAAADGRLKRGDQILSV 1799

Human  1908 NGETLEGVTHEQAVAILKHQRGTVTLTVLS 1937
            |||:||||||::||||||.|||.|||:|||
Frog  1800 NGESLEGVTHDEAVAILKKQRGNVTLSVLS 1829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PATJ	XP_011538764.1	L27_2	8..65	CDD:117611	36/56 (64%)
		PDZ_signaling	135..218	CDD:238492	53/82 (65%)
		PDZ_signaling	246..325	CDD:238492	66/78 (85%)
		PDZ_signaling	366..450	CDD:238492	54/83 (65%)
		PDZ_signaling	570..634	CDD:238492	54/63 (86%)
		PDZ	683..772	CDD:214570	61/88 (69%)
		PDZ_signaling	1066..1157	CDD:238492	79/90 (88%)
		PDZ	1236..1321	CDD:214570	71/84 (85%)
		PDZ	1459..1574	CDD:214570	77/114 (68%)
		PDZ_signaling	1586..1666	CDD:238492	69/79 (87%)
		PDZ_signaling	1729..1814	CDD:238492	70/84 (83%)
		PDZ_signaling	1852..1936	CDD:238492	69/83 (83%)
patj	XP_002931635.3	L27_2	13..70	CDD:312549	36/56 (64%)
		PDZ_signaling	142..225	CDD:238492	53/82 (65%)
		PDZ_signaling	256..328	CDD:238492	61/71 (86%)
		PDZ_signaling	364..449	CDD:238492	54/85 (64%)
		PDZ_signaling	556..620	CDD:238492	54/63 (86%)
		PDZ_signaling	692..770	CDD:238492	53/77 (69%)
		PDZ_signaling	1014..1105	CDD:238492	79/90 (88%)
		PDZ	1186..1271	CDD:214570	72/84 (86%)
		PDZ	1383..1468	CDD:214570	77/114 (68%)
		PDZ_signaling	1480..1560	CDD:238492	69/79 (87%)
		PDZ_signaling	1624..1709	CDD:238492	70/84 (83%)
		PDZ_signaling	1744..1828	CDD:238492	69/83 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	145	1.000	Domainoid score	I21972
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H72199
Inparanoid	1	1.050	1905	1.000	Inparanoid score	I783
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12016at7742
OrthoFinder	1	1.000	-	-		FOG0003499
OrthoInspector	1	1.000	-	-		oto155508
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060