Protein Alignment CALCRL and calcrl

DIOPT Version :10

• Sequence 1: XP_005246289.2
• Gene: CALCRL / 10203
• HGNCID: 16709
• Length: 472
• Species: Homo sapiens
• Sequence 2: XP_012825895.1
• Gene: calcrl / 549647
• XenbaseID: XB-GENE-5736126
• Length: 481
• Species: Xenopus tropicalis
• Alignment Length: 479
• Identity: 375/479 - (78%)
• Similarity: 418/479 - (87%)
• Gaps: 9/479 - (1%)

Human     1 MLYSIFHFGLMMEKKCTLYFLVLLPFFMI--LVTAELEESP----EDSIQLGVTRNKIMTAQYEC 59
            ::...|..||::......|.:::|....:  .|.||.|:..    |:.||:||||||||||||||
 Frog     3 LIIETFEMGLLLRSALFKYIIIVLIMLNLRGYVLAEQEQGSQIPLEEIIQVGVTRNKIMTAQYEC 67

Human    60 YQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFR 124
            ||||||:|....||.:|||||||||||.||:||..|.|.||||||||||||||||.|.::|:|||
 Frog    68 YQKIMQEPANGKEGHFCNRTWDGWLCWGDVSAGVISEQRCPDYFQDFDPSEKVTKECGKNGHWFR 132

Human   125 HPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHK 189
            ||.|||||||||:||..|||||||||||:|||||||||||||||||||||||||:||||||||||
 Frog   133 HPDSNRTWTNYTRCNTFTHEKVKTALNLYYLTIIGHGLSIASLLISLGIFFYFKNLSCQRITLHK 197

Human   190 NLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVV 254
            ||||||||||::|||.|:|||||||||||||||||:|||||||||||||||||||||||||||||
 Frog   198 NLFFSFVCNSIITIISLSAVANNQALVATNPVSCKISQFIHLYLMGCNYFWMLCEGIYLHTLIVV 262

Human   255 AVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFF 319
            |||||||||||||.||||||||||||||:||||||||||||||:|||||||||||||||||||||
 Frog   263 AVFAEKQHLMWYYLLGWGFPLIPACIHAVARSLYYNDNCWISSETHLLYIIHGPICAALLVNLFF 327

Human   320 LLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILM 384
            |||||||||||||||||||||||||||||||||||||||||||.||:|||:||||:|||:|||||
 Frog   328 LLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLFPWKPEGRIAEEIYDYVMHILM 392

Human   385 HFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISD--GPGYSHDC 447
            |:|||||:||||||||||||:|:|:|||||||||:||::||.|||||||||:||:  |..|:||.
 Frog   393 HYQGLLVATIFCFFNGEVQAVLKRHWNQYKIQFGSSFAHSEGLRSASYTVSSISEIQGTTYTHDY 457

Human   448 PSEHLNGKSIHDIENVLLKPENLY 471
             ||..|||:.||:|||..|.|..|
 Frog   458 -SEQSNGKNCHDMENVFFKTEKQY 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CALCRL	XP_005246289.2	HRM	73..141	CDD:397086	52/67 (78%)
		7tmB1_calcitonin_R	149..422	CDD:341343	251/272 (92%)
		TM helix 1	151..176	CDD:341343	23/24 (96%)
		TM helix 2	185..207	CDD:341343	18/21 (86%)
		TM helix 3	224..251	CDD:341343	25/26 (96%)
		TM helix 4	263..283	CDD:341343	18/19 (95%)
		TM helix 5	298..327	CDD:341343	27/28 (96%)
		TM helix 6	341..368	CDD:341343	24/26 (92%)
		TM helix 7	374..399	CDD:341343	20/24 (83%)
calcrl	XP_012825895.1	HRM	81..149	CDD:397086	52/67 (78%)
		7tmB1_calcitonin_R	157..429	CDD:341343	250/271 (92%)
		TM helix 1	159..184	CDD:341343	23/24 (96%)
		TM helix 2	193..215	CDD:341343	18/21 (86%)
		TM helix 3	232..259	CDD:341343	25/26 (96%)
		TM helix 4	271..291	CDD:341343	18/19 (95%)
		TM helix 5	306..335	CDD:341343	27/28 (96%)
		TM helix 6	349..376	CDD:341343	24/26 (92%)
		TM helix 7	382..407	CDD:341343	20/24 (83%)