Protein Alignment CALCRL and Calcrl

DIOPT Version :10

• Sequence 1: XP_005246289.2
• Gene: CALCRL / 10203
• HGNCID: 16709
• Length: 472
• Species: Homo sapiens
• Sequence 2: XP_006234501.1
• Gene: Calcrl / 25029
• RGDID: 2255
• Length: 464
• Species: Rattus norvegicus
• Alignment Length: 462
• Identity: 419/462 - (90%)
• Similarity: 435/462 - (94%)
• Gaps: 1/462 - (0%)

Human    11 MMEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVY 75
            ||:|||||.||.||...|.|:.||.||....: .||||||||||||||||||||||||||.||:|
  Rat     1 MMDKKCTLCFLFLLLLNMALIAAESEEGANQT-DLGVTRNKIMTAQYECYQKIMQDPIQQGEGLY 64

Human    76 CNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNV 140
            ||||||||||||||||||||||.||||||||||||||||||||||||||||.|||||||||.||.
  Rat    65 CNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGNWFRHPDSNRTWTNYTLCNN 129

Human   141 NTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIH 205
            :||||||||||||||||||||||||||:|||.|||||||||||||||||||||||||||:|||||
  Rat   130 STHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFVCNSIVTIIH 194

Human   206 LTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLG 270
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   195 LTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLG 259

Human   271 WGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTH 335
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   260 WGFPLLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTH 324

Human   336 QAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNG 400
            |||||||||||||||||||||||||||.|||||||:|||||||:||||||:||||||||||||||
  Rat   325 QAESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVAEEVYDYVMHILMHYQGLLVSTIFCFFNG 389

Human   401 EVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLL 465
            |||||||||||||||||||.||:|:||||||||||||||..|||||||:||||||||.|||||.|
  Rat   390 EVQAILRRNWNQYKIQFGNGFSHSDALRSASYTVSTISDVQGYSHDCPTEHLNGKSIQDIENVAL 454

Human   466 KPENLYN 472
            |||.:|:
  Rat   455 KPEKMYD 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CALCRL	XP_005246289.2	HRM	73..141	CDD:397086	63/67 (94%)
		7tmB1_calcitonin_R	149..422	CDD:341343	263/272 (97%)
		TM helix 1	151..176	CDD:341343	22/24 (92%)
		TM helix 2	185..207	CDD:341343	20/21 (95%)
		TM helix 3	224..251	CDD:341343	26/26 (100%)
		TM helix 4	263..283	CDD:341343	18/19 (95%)
		TM helix 5	298..327	CDD:341343	28/28 (100%)
		TM helix 6	341..368	CDD:341343	25/26 (96%)
		TM helix 7	374..399	CDD:341343	22/24 (92%)
Calcrl	XP_006234501.1	HRM	62..129	CDD:397086	62/66 (94%)
		7tmB1_calcitonin_R	138..411	CDD:341343	263/272 (97%)
		TM helix 1	140..165	CDD:341343	22/24 (92%)
		TM helix 2	174..196	CDD:341343	20/21 (95%)
		TM helix 3	213..240	CDD:341343	26/26 (100%)
		TM helix 4	252..272	CDD:341343	18/19 (95%)
		TM helix 5	287..316	CDD:341343	28/28 (100%)
		TM helix 6	330..357	CDD:341343	25/26 (96%)
		TM helix 7	363..388	CDD:341343	22/24 (92%)