Protein Alignment CDK5 and CkIIalpha

DIOPT Version :10

• Sequence 1: NP_004926.1
• Gene: CDK5 / 1020
• HGNCID: 1774
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_524918.1
• Gene: CkIIalpha / 48448
• FlyBaseID: FBgn0264492
• Length: 336
• Species: Drosophila melanogaster
• Alignment Length: 305
• Identity: 102/305 - (33%)
• Similarity: 160/305 - (52%)
• Gaps: 41/305 - (13%)

Human     4 YEKLEKIGEGTYGTVFKAKNRETHE---IVALKRVRLDDDDEGVPSSALREICLLKELK-HKNIV 64
            |:.:.|:|.|.|..||:|.|..|.|   :..||.|:        .....|||.:|:.|: ..||:
  Fly    37 YQLVRKLGRGKYSEVFEAINITTTEKCVVKILKPVK--------KKKIKREIKILENLRGGTNII 93

Human    65 RLHDVLHSDKKLT--LVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126
            .|..|:......|  |:||..:. |.|:.:.:..   |.|| :.:||:|||.|.:|||..::|||
  Fly    94 TLLAVVKDPVSRTPALIFEHVNNTDFKQLYQTLT---DYEI-RYYLFELLKALDYCHSMGIMHRD 154

Human   127 LKPQNLLI-NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGC 190
            :||.|::| :.|.:|:|.|:|||. |..|.:.|:..|.:.:::.|::|...::|..|:||||.||
  Fly   155 VKPHNVMIDHENRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGC 218

Human   191 IFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL-----PDY---------KPYPM 241
            :.|.:.....|.|.|:|..|||.||.::||  |||.:..:.|.     |.:         |.:..
  Fly   219 MLASMIFRKEPFFHGHDNYDQLVRIAKVLG--TEELYAYLDKYNIDLDPRFHDILQRHSRKRWER 281

Human   242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286
            :..:.:...|.|:    ..|.|..||:.:.|.|::|.||:.||||
  Fly   282 FVHSDNQHLVSPE----ALDFLDKLLRYDHVDRLTAREAMAHPYF 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK5	NP_004926.1	STKc_CDK5	3..286	CDD:143344	100/303 (33%)
CkIIalpha	NP_524918.1	STKc_CK2_alpha	18..322	CDD:271034	100/303 (33%)