Protein Alignment CDK5 and p38a

DIOPT Version :10

• Sequence 1: NP_004926.1
• Gene: CDK5 / 1020
• HGNCID: 1774
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_477163.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Alignment Length: 307
• Identity: 107/307 - (34%)
• Similarity: 155/307 - (50%)
• Gaps: 31/307 - (10%)

Human     4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68
            |:.|:.:|.|.||.|.||..|.|:..||:|::..............||:.|||.:.|:|::.|.|
  Fly    25 YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLD 89

Human    69 VLH---------SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124
            :.|         :.:::.||....|.||.......:  |..:.|:..::|:|:||.:.||..|:|
  Fly    90 IFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQH--LSDDHVQFLVYQILRGLKYIHSAGVIH 152

Human   125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAG 189
            |||||.|:.:|.:.||::.||||||.....:..|   |.|.|||.|:::.....|..::|:||.|
  Fly   153 RDLKPSNIAVNEDCELRILDFGLARPTENEMTGY---VATRWYRAPEIMLNWMHYDQTVDIWSVG 214

Human   190 CIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP---------TEEQWPSMTKLPDYKPYPMYPAT 245
            ||.|||... |.||||.|...||..|..:||||         :|.....:..||..|       .
  Fly   215 CIMAELITR-RTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMK-------G 271

Human   246 TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292
            .|..||....|....|||:.:|:.:..:||:|||||.|||...:..|
  Fly   272 RSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEP 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK5	NP_004926.1	STKc_CDK5	3..286	CDD:143344	105/299 (35%)
p38a	NP_477163.1	STKc_p38	9..354	CDD:143356	107/307 (35%)