Protein Alignment CDK5 and Cdk12

DIOPT Version :10

• Sequence 1: NP_004926.1
• Gene: CDK5 / 1020
• HGNCID: 1774
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Alignment Length: 315
• Identity: 128/315 - (40%)
• Similarity: 186/315 - (59%)
• Gaps: 42/315 - (13%)

Human     4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68
            :|.:.:|||||||.|:||::..|:::||||:|||:.:.||.|.:|:|||.:|::|.|:|||.||:
  Fly   804 FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHE 868

Human    69 VLHSDKK-----------LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122
            :: :||:           ..||||:.|.||....:|...|.:.|...|.:.|||.||.:||.:|.
  Fly   869 IV-TDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNF 932

Human   123 LHRDLKPQNLLINRNGELKLADFGLARAFGIP--VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDM 185
            ||||:|..|:|:|..|::|||||||||.:...  .|.|:.:|:|||||||::|.|.:.|..|||:
  Fly   933 LHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDV 997

Human   186 WSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY-------------- 236
            ||.|||..||. ..||||..|....||:.|.::.|:|....||::.|||.:
  Fly   998 WSCGCILGELF-VKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLR 1061

Human   237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291
            :.:...||        |.|     |||..:|..:|.:||:||:||:.|:.....|
  Fly  1062 EDFEFMPA--------PAL-----DLLDKMLDLDPDKRITAEDALRSPWLRKINP 1103

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK5	NP_004926.1	STKc_CDK5	3..286	CDD:143344	127/308 (41%)
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	127/308 (41%)