Protein Alignment CDK5 and Cdk8

DIOPT Version :10

• Sequence 1: NP_004926.1
• Gene: CDK5 / 1020
• HGNCID: 1774
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Alignment Length: 326
• Identity: 124/326 - (38%)
• Similarity: 181/326 - (55%)
• Gaps: 60/326 - (18%)

Human     9 KIGEGTYGTVFKAKNRETHE--IVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVL- 70
            |:|.||||.|:|||.:||.:  ..|||::    |..|:..||.|||.||:||||:|::.|..|.
  Fly    26 KVGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSMSACREIALLRELKHQNVITLIRVFL 86

Human    71 -HSDKKLTLVFEFCDQDL-------------KKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121
             |:|:|:.|:.::.:.||             ||......|     :|||.|:|:|.|:.:.||..
  Fly    87 SHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRG-----MVKSLLYQILDGIHYLHSNW 146

Human   122 VLHRDLKPQNLLI----NRNGELKLADFGLARAFGIPVRCYS---AEVVTLWYRPPDVLFGAKLY 179
            ||||||||.|:|:    |..|.:|:||.|.||.|..|::..:   ..|||.|||.|::|.||:.|
  Fly   147 VLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHY 211

Human   180 STSIDMWSAGCIFAELANAGRPLFPGNDVD---------DQLKRIFRLLGTPTEEQWPSMTKLP- 234
            :.:||:|:.|||||||..: .|:|.....|         |||.|||.::|.|.::.|..:.|:|
  Fly   212 TKAIDIWAIGCIFAELLTS-EPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPE 275

Human   235 ------DYK--PYPMYPATTSLVNVVP----KLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287
                  |:|  .|    :|.||...:.    |.::....|||.||..:|.:||::|:|:|..||.
  Fly   276 HHTLTKDFKRSTY----STCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQYFQ 336

Human   288 D 288
            :
  Fly   337 E 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK5	NP_004926.1	STKc_CDK5	3..286	CDD:143344	122/322 (38%)
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	122/322 (38%)