Protein Alignment CDK5 and Cdk9

DIOPT Version :10

• Sequence 1: NP_004926.1
• Gene: CDK5 / 1020
• HGNCID: 1774
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_477226.2
• Gene: Cdk9 / 37586
• FlyBaseID: FBgn0019949
• Length: 404
• Species: Drosophila melanogaster
• Alignment Length: 311
• Identity: 127/311 - (40%)
• Similarity: 176/311 - (56%)
• Gaps: 39/311 - (12%)

Human     3 KYEKLEKIGEGTYGTVFKAKNRE-THEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66
            ||||:.|||:||:|.||||:.:: ..:.||:|:|.:|::.||.|.:|||||.:|:.|||:|:|.|
  Fly    49 KYEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVNL 113

Human    67 HDVLHSDKKLT--------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123
            .::..:....|        |||:||:.||.....:.|.......:|..:.|||.||.:.||..:|
  Fly   114 IEICRTKATATNGYRSTFYLVFDFCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSNKIL 178

Human   124 HRDLKPQNLLINRNGELKLADFGLARAFGIP----VRCYSAEVVTLWYRPPDVLFGAKLYSTSID 184
            |||:|..|:||.::|.||||||||||||.||    ...|:..|||||||||::|.|.:.|...:|
  Fly   179 HRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYGPPVD 243

Human   185 MWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLV 249
            ||.||||.||:.... |:..||....||..|.:|.|:.|.:.||.:.:|..||...:
  Fly   244 MWGAGCIMAEMWTRS-PIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIEL-------- 299

Human   250 NVVPK--------------LNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286
               ||              .:.||.|||..||..:|.:||.|:.||.|.:|
  Fly   300 ---PKNQKRRVKERLRPYVKDQTGCDLLDKLLTLDPKKRIDADTALNHDFF 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK5	NP_004926.1	STKc_CDK5	3..286	CDD:143344	126/309 (41%)
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	126/309 (41%)