Protein Alignment CDK5 and Cdc2rk

DIOPT Version :10

• Sequence 1: NP_004926.1
• Gene: CDK5 / 1020
• HGNCID: 1774
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_523674.1
• Gene: Cdc2rk / 36051
• FlyBaseID: FBgn0013435
• Length: 387
• Species: Drosophila melanogaster
• Alignment Length: 304
• Identity: 130/304 - (42%)
• Similarity: 185/304 - (60%)
• Gaps: 24/304 - (7%)

Human     1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65
            :.::|||.::|||:||.|::|::..::||||||:||:|.:.:|:|.|.||||.:||:..|:||||
  Fly    50 VSEFEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHENIVR 114

Human    66 LHDVL--HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128
            |.:|:  .|...:.||.:||:|||....|:.:.......||....|:||.|.:.|||.::|||||
  Fly   115 LREVVVGKSLDSIFLVMDFCEQDLASVLDNMSQPFTESEVKCITLQVLKALKYLHSRFMIHRDLK 179

Human   129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFA 193
            ..|||:...|.:|:|||||||.|..|.:..:.::||||||.|::|.|.:.::|::|||:.|||..
  Fly   180 VSNLLMTDKGCIKVADFGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILG 244

Human   194 ELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP-------DYKPYPMYPATTSLVNV 251
            ||. .|:||.|||....||..|..|||.|:|..||....||       ..:||.         |:
  Fly   245 ELL-LGKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYN---------NL 299

Human   252 VPK---LNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292
            .||   :..:||:||..|...||..|.:|||.|:..||.|  ||
  Fly   300 TPKFHMIGQSGRNLLNILFIYNPKTRATAEECLKSKYFVD--PP 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK5	NP_004926.1	STKc_CDK5	3..286	CDD:143344	125/294 (43%)
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	130/304 (43%)