Protein Alignment CDK5 and p38b

DIOPT Version :10

• Sequence 1: NP_004926.1
• Gene: CDK5 / 1020
• HGNCID: 1774
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_477361.1
• Gene: p38b / 34780
• FlyBaseID: FBgn0024846
• Length: 365
• Species: Drosophila melanogaster
• Alignment Length: 306
• Identity: 104/306 - (33%)
• Similarity: 160/306 - (52%)
• Gaps: 25/306 - (8%)

Human     2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66
            :.|:.|:.:|:|.||.|.||..|.|...||:|::..............||:.|||.:.|:|::.|
  Fly    22 ETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGL 86

Human    67 HDVLHSD---------KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122
            .||.|..         :::.:|....|.||.....:  ..|..:.|:..::|:|:||.:.||..|
  Fly    87 LDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRT--QKLSDDHVQFLVYQILRGLKYIHSAGV 149

Human   123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWS 187
            :||||||.|:.:|.:.||::.||||||.....:..|   |.|.|||.|:::.....|:.:.|:||
  Fly   150 IHRDLKPSNIAVNEDCELRILDFGLARPAESEMTGY---VATRWYRAPEIMLNWMHYNQTADIWS 211

Human   188 AGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD------YKPYPMYPATT 246
            .|||.|||. .||.||||.|...||..|..:||||.:|   .|:::..      .:..|:.| ..
  Fly   212 VGCIMAELL-TGRTLFPGTDHIHQLNLIMEVLGTPADE---FMSRISSESARNYIRSLPVMP-RR 271

Human   247 SLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292
            :..::....|....|||:.:|:.:..:||:||:||.|||...:..|
  Fly   272 NFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDP 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK5	NP_004926.1	STKc_CDK5	3..286	CDD:143344	102/297 (34%)
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	104/306 (34%)