Protein Alignment CDK5 and CG42366

DIOPT Version :10

• Sequence 1: NP_004926.1
• Gene: CDK5 / 1020
• HGNCID: 1774
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Alignment Length: 300
• Identity: 118/300 - (39%)
• Similarity: 177/300 - (59%)
• Gaps: 30/300 - (10%)

Human     1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD--DDDEGVPSSALREICLLKELKHKNI 63
            |.:|..|.::|:||||||...:.::|.|.||:||::..  ..:|.:   .|||:..||:|.|.||
  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAM---NLREVKSLKKLSHPNI 62

Human    64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDL-DPEIVKSFLFQLLKGLGFCHSRNVLHRDL 127
            |:|.:|:..:..|..|||:..::|.:.....:..| :||: ||.|||:|.||.|.|.....||||
  Fly    63 VKLKEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPEL-KSILFQVLTGLAFMHRHGFFHRDL 126

Human   128 KPQNLLINRNGELKLADFGLARAFGIPVRC---YSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAG 189
            ||:|||.:....:|:|||||||    .:|.   ::..|.|.|||.|:||..:..|.::||:|:.|
  Fly   127 KPENLLCSGPDLIKIADFGLAR----EIRSRPPFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMG 187

Human   190 CIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL--------PDYKPYPMYPATT 246
            ||.|||... ||||||:...|||.:|..:||||.::.||...:|        ||....|
  Fly   188 CIMAELYTF-RPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCIKVP------ 245

Human   247 SLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286
             |.:||.:.:..|.|||:::|..:|.:|.:|:::|::|||
  Fly   246 -LSSVVSRCSQNGLDLLEDMLAYDPDKRPTAQQSLKYPYF 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK5	NP_004926.1	STKc_CDK5	3..286	CDD:143344	115/296 (39%)
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	115/295 (39%)