Protein Alignment CDK5 and rl

DIOPT Version :10

• Sequence 1: NP_004926.1
• Gene: CDK5 / 1020
• HGNCID: 1774
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Alignment Length: 307
• Identity: 113/307 - (36%)
• Similarity: 163/307 - (53%)
• Gaps: 28/307 - (9%)

Human     3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67
            :|.||..||||.||.|..|.:..|::.||:|::. ..:.:......||||.:|...||:||:.:.
  Fly    37 RYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKIS-PFEHQTYCQRTLREITILTRFKHENIIDIR 100

Human    68 DVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD-PEIVKS----------FLFQLLKGLGFCHSRN 121
            |:|..|.        .||....|...|..:.| .:::|:          ||:|:|:||.:.||.|
  Fly   101 DILRVDS--------IDQMRDVYIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKYIHSAN 157

Human   122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA----EVVTLWYRPPDVLFGAKLYSTS 182
            ||||||||.|||:|:..:||:.|||||| ...|...::.    .|.|.|||.|:::..:|.|:.|
  Fly   158 VLHRDLKPSNLLLNKTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 221

Human   183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM--TKLPDYKPYPMYPAT 245
            ||:||.|||.||:. :.||:|||....|||..|..:||:|:.:....:  .|..:|.....:...
  Fly   222 IDIWSVGCILAEML-SNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPN 285

Human   246 TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292
            .....:.|..:|...|||..:|..||.:||..||||.|||...:..|
  Fly   286 VPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDP 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK5	NP_004926.1	STKc_CDK5	3..286	CDD:143344	111/299 (37%)
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	113/307 (37%)