Protein Alignment CDK5 and cdk-5

DIOPT Version :9

• Sequence 1: NP_004926.1
• Gene: CDK5 / 1020
• HGNCID: 1774
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_499783.1
• Gene: cdk-5 / 176774
• WormBaseID: WBGene00000407
• Length: 292
• Species: Caenorhabditis elegans
• Alignment Length: 288
• Identity: 215/288 - (74%)
• Similarity: 254/288 - (88%)
• Gaps: 0/288 - (0%)

Human     1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65
            |..|:|:||||||||||||||:|:.:.||||||||||||||||||||||||||:|:||||:|:||
 Worm     1 MLNYDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILRELKHRNVVR 65

Human    66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQ 130
            |:||:||:.|||||||:|||||||:|||.||.:|.:..:|.:.|||:||.|||:.:|||||||||
 Worm    66 LYDVVHSENKLTLVFEYCDQDLKKFFDSLNGYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQ 130

Human   131 NLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL 195
            |||||.||.|||||||||||||:||||:|||||||||||||||||||||:||||||||||||||:
 Worm   131 NLLINTNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEI 195

Human   196 ANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGR 260
            :|||||||||.||||||||||:.||:|:|:.|||:|:||||||||:|..|.:...:||.||:.||
 Worm   196 SNAGRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLPDYKPYPIYHPTLTWSQIVPNLNSRGR 260

Human   261 DLLQNLLKCNPVQRISAEEALQHPYFSD 288
            ||||.||.|||..||.|:.||:|.||:|
 Worm   261 DLLQKLLVCNPAGRIDADAALRHAYFAD 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK5	NP_004926.1	STKc_CDK5	3..286	CDD:143344	211/282 (75%)
cdk-5	NP_499783.1	PLN00009	1..292	CDD:177649	215/288 (75%)
		STKc_CDK5	3..286	CDD:143344	211/282 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	459	1.000	Domainoid score	I258
eggNOG	1	0.900	-	-		E1_KOG0662
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3623
Inparanoid	1	1.050	463	1.000	Inparanoid score	I938
Isobase	1	0.950	-	0	Normalized mean entropy	S244
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	1	1.000	-	-		FOG0000411
OrthoInspector	1	1.000	-	-		oto23187
orthoMCL	1	0.900	-	-		OOG6_100334
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R185
SonicParanoid	1	1.000	-	-		X3829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810