DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADAM10 and kuz

DIOPT Version :9

Sequence 1:	NP_001101.1	Gene:	ADAM10 / 102	HGNCID:	188	Length:	748	Species:	Homo sapiens
Sequence 2:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster

Alignment Length:	982	Identity:	340/982 - (34%)
Similarity:	474/982 - (48%)	Gaps:	250/982 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     7 LILLLSWAAGMGG-QYGNP-LNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGR 69
            :|::..:|..:.| :.|:. ||:||.|||.|:|:.:.:...|.||:|:|: :||::.|.|.:|||
  Fly    17 IIIVNGYAKDISGVKRGHERLNEYISHYETLNYDHEHIRASHNRARRSVT-KDQYVHLKFASHGR 80

Human    70 HFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGT 134
            .|:||:|||.:.||::.....|...:|..|.|||.|.:.|:..|:..||:.:|.|||.|.|....
  Fly    81 DFHLRLKRDLNTFSNKLDFYDSKGPIDVSTDHIYEGEVIGDRNSYVFGSIHNGVFEGKIITERDA 145

Human   135 FYVEPAERYI------------------------------------------------------- 144
            :|||.|:.|.
  Fly   146 YYVEHAKHYFPTNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKKIAE 210

Human   145 --------------------------------KDRT----LPFHSVIY---HEDDINYPHKYGPQ 170
                                            |:|.    |.|||:||   |.:|.....:.|..
  Fly   211 STTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHV 275

Human   171 GGCA-DHSVFERMRKYQMTGVEEVTQ------------------IPQEEHAANGP---------- 206
            .||. ...|.:.|...|.:.|||:.:                  .||::...:.|
  Fly   276 AGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDF 340

Human   207 -----------------------------------------ELLRKKRTTSA------------- 217
                                                     |.:|:.....|
  Fly   341 KYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGR 405

Human   218 --EKNTCQLYIQTDHLFFKYY-----------------GTREAVIAQISSHVKAIDTIYQTTDFS 263
              .||||.||||||.|.:::.                 .|||.:.:.|:.||.|::.||:.|.|.
  Fly   406 EDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFD 470

Human   264 G---IRNISFMVKRIRINTTA----DEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDR 321
            |   .|||.|.|:||:|:..:    ....|.|.|...::.|..||.|:|.::|.|:|||||||.|
  Fly   471 GRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYR 535

Human   322 DFDDGVLGLAWVGAPSGSSGGICEKSKLYSD-------GKKKSLNTGIITVQNYGSHVPPKVSHI 379
            ||..|.||||||.:.||:|||||||.|.|::       ..|:||||||||..||.|.||||||.:
  Fly   536 DFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQL 600

Human   380 TFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVL 444
            |.|||:|||||||||...||.||..       ||||||:|.|||||:.||:|||.|||||||.||
  Fly   601 TLAHEIGHNFGSPHDYPQECRPGGL-------NGNYIMFASATSGDRPNNSKFSPCSIRNISNVL 658

Human   445 E----KKRNNCFVESGQPICGNGMVEQGEECDCGYS-DQCKDECCF--------DANQPEGRKCK 496
            :    ..:.:||..|....|||.:||.|||||||:: ::|||:||:        .:.....:.|.
  Fly   659 DVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCT 723

Human   497 LKPGKQCSPSQGPCCTA-QCAF--KSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRH 558
            .:...||||||||||.: .|.|  .|..:||:::::|:....|||.||.||....:.:.|.||..
  Fly   724 RRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNGTTAECPEPRHRDDKTMCNNG 788

Human   559 TQVCINGQCAGSICEKYGLEEC--TCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSG 621
            |.:||.|:|:||.|..:.:.:|  |..:......::||.:.|....|.|||.||.......:...
  Fly   789 TALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQK 853

Human   622 RTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGI 686
            ..|:|||||||::|:||||||::||.|||||||.|||..:.:.:..:.:|||||.:|:.|:|||:
  Fly   854 GGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGV 918

Human   687 ALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQR---QR-------PRESY 741
            |.|::|..|||.|:|||||||||....:.:..||  |.|...:::.||   ||       |..::
  Fly   919 AFIVVMGSFIKCCAVHTPSSNPKKRRARRISETL--RAPMNTLRRMQRHPNQRGAGPRSIPPPAH 981

Human   742 QMGHMRR 748
            :..|..|
  Fly   982 EAQHYSR 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADAM10	NP_001101.1	Pep_M12B_propep	46..156	CDD:396235	48/200 (24%)
		Cysteine switch. /evidence=ECO:0000250	171..178		2/7 (29%)
		ZnMc_TACE_like	220..459	CDD:239798	132/273 (48%)
		DISIN	466..545	CDD:214490	36/90 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..748		16/53 (30%)
		SH3-binding. /evidence=ECO:0000255	708..715		2/6 (33%)
		SH3-binding. /evidence=ECO:0000255	722..728		2/5 (40%)
		Interaction with AP2A1, AP2A2 and AP2M1. /evidence=ECO:0000250\|UniProtKB:O35598	734..748		5/23 (22%)
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	132/273 (48%)
		Reprolysin_2	450..659	CDD:290307	115/215 (53%)
		Disintegrin	684..776	CDD:278623	37/91 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146046
Domainoid	1	1.000	213	1.000	Domainoid score	I2764
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	584	1.000	Inparanoid score	I1012
Isobase	1	0.950	-	0	Normalized mean entropy	S4570
OMA	1	1.010	-	-		QHG48710
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0006327
OrthoInspector	1	1.000	-	-		oto88414
orthoMCL	1	0.900	-	-		OOG6_104685
Panther	1	1.100	-	-	LDO	PTHR45702
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3274
SonicParanoid	1	1.000	-	-		X3482
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.890