DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDK4 and msn

DIOPT Version :9

Sequence 1:	NP_000066.1	Gene:	CDK4 / 1019	HGNCID:	1773	Length:	303	Species:	Homo sapiens
Sequence 2:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster

Alignment Length:	305	Identity:	80/305 - (26%)
Similarity:	137/305 - (44%)	Gaps:	48/305 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70
            :|.:..:|.|.||.|||.|...:|...|:|.:.|.........|.|:.:::.:..|.:..:....
  Fly    32 FELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAF 96

Human    71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPP-PGLPAETIKDLMRQFLRGLDFLHAN 134
            :.:       |...::.::.||.|:......|.|.|:.. ..|..|.|..:.|:.||||.:||:|
  Fly    97 IKK-------SPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSN 154

Human   135 CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT-----PVVVTLWYRAPEVLL-----QS 189
            .::|||:|.:|:|:|....|||.|||:    |.|:..|     ..:.|.::.||||:.     .:
  Fly   155 KVIHRDIKGQNVLLTDNAEVKLVDFGV----SAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDA 215

Human   190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGP 254
            ||....|:||:|....||...:|..|   :...:..:|               .:||.: |||
  Fly   216 TYDNRSDLWSLGITALEMAESQPPLC---DLHPMRALF---------------LIPRNS-PPR-- 259

Human   255 RPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299
              ::|.....:..|  .:..:|..:.|:|......|:|.:: ||:
  Fly   260 --LKSKKWSKKFHG--FIDTVLVKDYHQRPYTENLLKHGFI-KDQ 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDK4	NP_000066.1	PKc_like	5..295	CDD:389743	78/299 (26%)
CDK4	NP_000066.1	Required for binding D-type cyclins	50..56		1/5 (20%)
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	78/299 (26%)
		S_TKc	32..296	CDD:214567	78/299 (26%)
		CNH	1183..1484	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910