Protein Alignment CDK4 and Cdk2

DIOPT Version :9

• Sequence 1: NP_000066.1
• Gene: CDK4 / 1019
• HGNCID: 1773
• Length: 303
• Species: Homo sapiens
• Sequence 2: NP_001163666.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Alignment Length: 301
• Identity: 131/301 - (43%)
• Similarity: 185/301 - (61%)
• Gaps: 22/301 - (7%)

Human     6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70
            ::...:||.|.||.|||||...:|..||||.:|:.   |...|:|.:.:||::||:.|   :|||
  Fly     8 FQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLE---GETEGVPSTAIREISLLKNL---KHPN 66

Human    71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC 135
            ||:|.||..:..     .:.::||:::.||:..:||......| :.||..|.|.|..:.|.|.|.
  Fly    67 VVQLFDVVISGN-----NLYMIFEYLNMDLKKLMDKKKDVFTP-QLIKSYMHQILDAVGFCHTNR 125

Human   136 IVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPEVLLQST-YATPVDMW 198
            |:||||||:|:||.:.|.:|||||||||.::..| |.|..||||||||||:||.:. |:|.||:|
  Fly   126 ILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIW 190

Human   199 SVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPE 263
            |:||||:||..|:.||.|:||.|||.:||..:..|.|.:||....||  .|..:.||...:.:|:
  Fly   191 SLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLP--DFKTKFPRWEGTNMPQ 253

Human   264 --MEESGAQLLLEMLTFNPHKRISAFRALQHSYL----HKD 298
              .|....:|::.||.::|:.||||..||||:|.    |.|
  Fly   254 PITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVD 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK4	NP_000066.1	PKc_like	5..295	CDD:389743	128/292 (44%)
		Required for binding D-type cyclins	50..56		1/5 (20%)
Cdk2	NP_001163666.1	PLN00009	5..293	CDD:177649	129/298 (43%)
		STKc_CDK1_CdkB_like	8..287	CDD:270829	128/292 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810