Protein Alignment CDK4 and Cdk4

DIOPT Version :9

• Sequence 1: NP_000066.1
• Gene: CDK4 / 1019
• HGNCID: 1773
• Length: 303
• Species: Homo sapiens
• Sequence 2: NP_001286493.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Alignment Length: 293
• Identity: 139/293 - (47%)
• Similarity: 195/293 - (66%)
• Gaps: 3/293 - (1%)

Human     6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70
            |:.:..||.|||||||:|||..:|:.||||.||:   .....|:|:||:||::||::|.|..|.|
  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRI---SLNENGVPMSTLREISLLKQLNASNHAN 87

Human    71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC 135
            :|:|.:||.....|.::.:.||||||:|||...:|:.|..|:...||:.|.|:.|.|:||||::.
  Fly    88 IVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHR 152

Human   136 IVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSV 200
            |:||||||:|:||:|.|.:|:||||||:.|..:|.||.||||||||||||||...|.:.||:||.
  Fly   153 IIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLLAQPYNSTVDIWSA 217

Human   201 GCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEME 265
            .||..|||.|:.||.|.||.:||.:||:|.|.|.|..||:.:|:....||.|.|:..:...|.:.
  Fly   218 ACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDFCPHLC 282

Human   266 ESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298
            :....||.:||:::.|.|.||...|:|.|..::
  Fly   283 KYADDLLNKMLSYDLHLRPSALACLEHDYFQQE 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK4	NP_000066.1	PKc_like	5..295	CDD:389743	138/288 (48%)
		Required for binding D-type cyclins	50..56		3/5 (60%)
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	138/288 (48%)
		S_TKc	26..312	CDD:214567	138/288 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1720
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2907
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D419040at33208
OrthoFinder	1	1.000	-	-		FOG0004605
OrthoInspector	1	1.000	-	-		otm41504
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5120
SonicParanoid	1	1.000	-	-		X2222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.960