Protein Alignment CDK4 and cdk6

DIOPT Version :9

• Sequence 1: NP_000066.1
• Gene: CDK4 / 1019
• HGNCID: 1773
• Length: 303
• Species: Homo sapiens
• Sequence 2: XP_002934637.2
• Gene: cdk6 / 100489734
• XenbaseID: XB-GENE-985427
• Length: 333
• Species: Xenopus tropicalis
• Alignment Length: 297
• Identity: 209/297 - (70%)
• Similarity: 245/297 - (82%)
• Gaps: 4/297 - (1%)

Human     1 MATSRYEPVAEIGVGAYGTVYKARD-PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64
            :|..:||.|||||.||||.|:|||| .:.|.|||||.|||..   |..|:|:||:||||:||.||
 Frog    10 LADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT---GEEGMPLSTIREVAVLRHLE 71

Human    65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129
            .|||||||||.|||..||||||.|:|||||||||||.|||||.|.||:|:|.|||:|.|.|||||
 Frog    72 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPDPGVPSEIIKDMMLQLLRGLD 136

Human   130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATP 194
            |||::.:|||||||:||||||.|.:||||||||||||:|||||.||||||||||||||||:||||
 Frog   137 FLHSHRVVHRDLKPQNILVTSNGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATP 201

Human   195 VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQS 259
            ||:|||||||||||||||||.|||:.||||||||:||||.|::||.||::||.||..|.|:|:::
 Frog   202 VDLWSVGCIFAEMFRRKPLFRGNSDVDQLGKIFDVIGLPEEEEWPHDVAVPRNAFHFRQPQPIEN 266

Human   260 VVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296
            |||.::|.|..||::.|||:|..||||:.||.|.|.|
 Frog   267 VVPGIDEQGKDLLIKCLTFSPANRISAYSALSHPYFH 303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK4	NP_000066.1	PKc_like	5..295	CDD:389743	206/290 (71%)
		Required for binding D-type cyclins	50..56		3/5 (60%)
cdk6	XP_002934637.2	STKc_CDK6	13..302	CDD:270846	206/291 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D187506at32523
OrthoFinder	1	1.000	-	-		FOG0004605
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010