DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amfrb and amfr

DIOPT Version :9

Sequence 1:	XP_005169066.1	Gene:	amfrb / 101884807	ZFINID:	ZDB-GENE-130530-643	Length:	459	Species:	Danio rerio
Sequence 2:	NP_001017083.1	Gene:	amfr / 549837	XenbaseID:	XB-GENE-923086	Length:	635	Species:	Xenopus tropicalis

Alignment Length:	446	Identity:	210/446 - (47%)
Similarity:	295/446 - (66%)	Gaps:	15/446 - (3%)

- Green bases have known domain annotations that are detailed below.

Zfish     6 WPCTQAYTAFSACLLTGCIYSLYDDEDKDLLIEKNLSQDSPSGRTDDDNVNNEELYSTGLWCHTT 70
            ||..:.||..|..||...:.|.|.....:......|..:....:...:.|:..||:.    ...:
Frog    11 WPSLRTYTGLSGLLLGLSLLSAYRSLSGEAAERSMLEGEEAGAQLPPEPVDLVELFR----YLVS 71

Zfish    71 GSLCMWVLVNTLCCFLLLMGKCIQLVVFGDLRINEKQNLKDKTWNFLFNKLIFLFGVLNVRTERE 135
            .||.:||||||:||.|:|:.|.||.||||.||:.|:|:||||.|||:|.|.||:||||||:|..|
Frog    72 DSLGVWVLVNTVCCLLMLIAKLIQHVVFGPLRVGERQHLKDKFWNFIFYKFIFIFGVLNVQTVEE 136

Zfish   136 MAMWCLCFSALLFLQLLAQLCKDRFEFLSSSPSSTALGSHMHLLLVLMCLFVSSGGLTIICVLLG 200
            :.:|.|.|:.||||.|:.||||||||:||.|| :|.:..||.:|::|..:.::..||.::|.:.|
Frog   137 VVLWFLWFAGLLFLHLMVQLCKDRFEYLSFSP-TTPMSCHMRVLVLLNIMLLACCGLAVLCAIAG 200

Zfish   201 FSFGMHTLSFMAVECLMVSVYVNHSILRYAIHLYDLMCDSSWEGKEVFIYYTDFVMEMGILLLDM 265
            ::.|||||:|||.||::|:....|.:|||.|||:||..:.:||||..::||||||||:..|.:|:
Frog   201 YTHGMHTLAFMAAECMLVTTRTTHVVLRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELSHLSIDL 265

Zfish   266 MHHINMLLYGNVWFSVADLFILTHIRFLAKEMQRKLFQHKNYMHIYDVMDTRFSMATMEELASRD 330
            ||||:|||:||:|.|:|.|.|...:|.|..|.||::.:||||:.:...|:..|::||.|||.:..
Frog   266 MHHIHMLLFGNIWLSMASLVIFMQLRHLFHEFQRRIRRHKNYLRVVGNMEAHFAVATPEELEANS 330

Zfish   331 DRCVICWEKMYTAYKLPCGHLFHKSCLRSWLEQNMSCPTCRMSVNMSGG-------HTGNEQEGA 388
            |.|.|||:.|.:|.|||||||||.|||||||||:.||||||||:||:.|       ...|:.:.|
Frog   331 DDCAICWDSMQSARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNMADGTRTRVEQQRENQDQNA 395

Zfish   389 LFSLGATDVPSRPPTRYHSQLFHFNGSQISNWLPGFSVEVLHSPNLIILLQADDSR 444
            : .|..|:  .||...:|:..|||:||:.::|||.|||||:|:.|::.|.||.:|:
Frog   396 V-PLAVTE--GRPRLNHHNHFFHFDGSRFASWLPSFSVEVMHTTNILGLAQASNSQ 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amfrb	XP_005169066.1	HRD1	77..>403	CDD:227568	174/332 (52%)
amfrb	XP_005169066.1	zf-RING_2	331..371	CDD:290367	29/39 (74%)
amfr	NP_001017083.1	HRD1	75..>374	CDD:227568	165/299 (55%)
		RING-H2_AMFR	331..374	CDD:319369	32/42 (76%)
		RING-H2 finger (C3H2C3-type)	333..370	CDD:319369	27/36 (75%)
		CUE_AMFR	450..490	CDD:270604
		G2BR	564..589	CDD:375868
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D149264at7742
OrthoFinder	1	1.000	-	-		FOG0006872
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3836
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010