DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amfrb and Amfr

DIOPT Version :9

Sequence 1:	XP_005169066.1	Gene:	amfrb / 101884807	ZFINID:	ZDB-GENE-130530-643	Length:	459	Species:	Danio rerio
Sequence 2:	XP_038954087.1	Gene:	Amfr / 361367	RGDID:	1311551	Length:	643	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	226/475 - (47%)
Similarity:	308/475 - (64%)	Gaps:	43/475 - (9%)

- Green bases have known domain annotations that are detailed below.

Zfish     6 WPCTQAYTAFSACLLTGCIYSLYDDEDKDLLIEKNLSQ-DSPSGRTD--DDNVNNEELYSTGLWC 67
            ||..:.||..|...|.|.|.|.|          :.||| :..||..:  ...:..|.|....|
  Rat    11 WPSLRTYTGLSGLALLGTIVSAY----------RALSQPEDGSGEPEPLTAPLQPEALAPARL-- 63

Zfish    68 HTTG--------------SLCMWVLVNTLCCFLLLMGKCIQLVVFGDLRINEKQNLKDKTWNFLF 118
             |.|              ||.:||||||.||.|:|:.|.||.:|||.||::|:|:||||.|||:|
  Rat    64 -TPGGPRVRDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIF 127

Zfish   119 NKLIFLFGVLNVRTEREMAMWCLCFSALLFLQLLAQLCKDRFEFLSSSPSSTALGSHMHLLLVLM 183
            .|.||:||||||:|..|:.||||.|:.|:||.|:.||||||||:||.|| :|.:.||..:|.:|:
  Rat   128 YKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSP-TTPMSSHGRVLSLLI 191

Zfish   184 CLFVSSGGLTIICVLLGFSFGMHTLSFMAVECLMVSVYVNHSILRYAIHLYDLMCDSSWEGKEVF 248
            .:.:|..||.::|.:.|::.|||||:|||.|.|:|:|...|.||||.|||:||..:.:||||..:
  Rat   192 AMLLSCCGLAVVCCVTGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTY 256

Zfish   249 IYYTDFVMEMGILLLDMMHHINMLLYGNVWFSVADLFILTHIRFLAKEMQRKLFQHKNYMHIYDV 313
            :||||||||:.:|.||:||||:|||:||:|.|:|.|.|...:|:|..|:||::.:||||:.:...
  Rat   257 VYYTDFVMELMLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGN 321

Zfish   314 MDTRFSMATMEELASRDDRCVICWEKMYTAYKLPCGHLFHKSCLRSWLEQNMSCPTCRMSVNMSG 378
            |:.||::||.||||..:|.|.|||:.|..|.|||||||||.|||||||||:.||||||||:|::.
  Rat   322 MEARFAVATAEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIAD 386

Zfish   379 G------HTGNEQEGALFSLGATDVPSRPPTRYHSQLFHFNGSQISNWLPGFSVEVLHSPNLIIL 437
            |      |.|...:..|..:.|.:  .||....|:..|||:||:|::|||.|||||:|:.|::.:
  Rat   387 GSRAREDHQGENLDENLVPVAAAE--GRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGI 449

Zfish   438 LQADDSR----GHQDEEIVP 453
            .||.:|:    .||.:|:.|
  Rat   450 TQASNSQLNAMAHQIQEMFP 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amfrb	XP_005169066.1	HRD1	77..>403	CDD:227568	179/331 (54%)
amfrb	XP_005169066.1	zf-RING_2	331..371	CDD:290367	29/39 (74%)
Amfr	XP_038954087.1	HRD1	86..>382	CDD:227568	170/296 (57%)
		RING-H2_AMFR	339..382	CDD:319369	32/42 (76%)
		CUE_AMFR	458..498	CDD:270604	4/12 (33%)
		G2BR	575..600	CDD:375868
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D149264at7742
OrthoFinder	1	1.000	-	-		FOG0006872
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3836
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920