DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amfrb and Amfr

DIOPT Version :9

Sequence 1:	XP_005169066.1	Gene:	amfrb / 101884807	ZFINID:	ZDB-GENE-130530-643	Length:	459	Species:	Danio rerio
Sequence 2:	NP_035917.2	Gene:	Amfr / 23802	MGIID:	1345634	Length:	639	Species:	Mus musculus

Alignment Length:	471	Identity:	222/471 - (47%)
Similarity:	305/471 - (64%)	Gaps:	39/471 - (8%)

- Green bases have known domain annotations that are detailed below.

Zfish     6 WPCTQAYTAFSACLLTGCIYSLY----DDED---------KDLLIEKNLSQDSPSGRTDDDNVNN 57
            ||..:.||..|...|.|.|.|.|    ..||         ..|..|..|:...|..|.....:.:
Mouse    11 WPSLRTYTGLSGLALLGTIVSAYRALSQPEDGSGEPEPLTAPLQPEARLTAGGPRARDVAQYLLS 75

Zfish    58 EELYSTGLWCHTTGSLCMWVLVNTLCCFLLLMGKCIQLVVFGDLRINEKQNLKDKTWNFLFNKLI 122
            :.|:             :||||||.||.|:|:.|.||.:|||.||::|:|:||||.|||:|.|.|
Mouse    76 DSLF-------------VWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFI 127

Zfish   123 FLFGVLNVRTEREMAMWCLCFSALLFLQLLAQLCKDRFEFLSSSPSSTALGSHMHLLLVLMCLFV 187
            |:||||||:|..|:.||||.|:.|:||.|:.||||||||:||.|| :|.:.||..:|.:|:.:.:
Mouse   128 FIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSP-TTPMSSHGRVLSLLIAMLL 191

Zfish   188 SSGGLTIICVLLGFSFGMHTLSFMAVECLMVSVYVNHSILRYAIHLYDLMCDSSWEGKEVFIYYT 252
            |..||.::|.:.|::.|||||:|||.|.|:|:|...|.||||.|||:||..:.:||||..::|||
Mouse   192 SCCGLAVVCCVTGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYT 256

Zfish   253 DFVMEMGILLLDMMHHINMLLYGNVWFSVADLFILTHIRFLAKEMQRKLFQHKNYMHIYDVMDTR 317
            |||||:.:|.||:||||:|||:||:|.|:|.|.|...:|:|..|:||::.:||||:.:...|:.|
Mouse   257 DFVMELALLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEAR 321

Zfish   318 FSMATMEELASRDDRCVICWEKMYTAYKLPCGHLFHKSCLRSWLEQNMSCPTCRMSVNMSGG--- 379
            |::||.||||..:|.|.|||:.|..|.|||||||||.|||||||||:.||||||||:|::.|
Mouse   322 FAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADGSRA 386

Zfish   380 ---HTGNEQEGALFSLGATDVPSRPPTRYHSQLFHFNGSQISNWLPGFSVEVLHSPNLIILLQAD 441
               |.|...:..|..:.|.:  .||....|:..|||:||:|::|||.|||||:|:.|::.:.||.
Mouse   387 REDHQGENLDENLVPVAAAE--GRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQAS 449

Zfish   442 DSR----GHQDEEIVP 453
            :|:    .||.:|:.|
Mouse   450 NSQLNAMAHQIQEMFP 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amfrb	XP_005169066.1	HRD1	77..>403	CDD:227568	179/331 (54%)
amfrb	XP_005169066.1	zf-RING_2	331..371	CDD:290367	29/39 (74%)
Amfr	NP_035917.2	HRD1	82..>378	CDD:227568	170/296 (57%)
		zf-RING_2	335..375	CDD:290367	29/39 (74%)
		CUE_AMFR	454..494	CDD:270604	4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..531
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..620
		VCP/p97-interacting motif (VIM). /evidence=ECO:0000250\|UniProtKB:Q9UKV5	618..636
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006872
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3836
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	5	5.410