DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amfrb and hrdl-1

DIOPT Version :9

Sequence 1:	XP_005169066.1	Gene:	amfrb / 101884807	ZFINID:	ZDB-GENE-130530-643	Length:	459	Species:	Danio rerio
Sequence 2:	NP_492602.2	Gene:	hrdl-1 / 172833	WormBaseID:	WBGene00009164	Length:	579	Species:	Caenorhabditis elegans

Alignment Length:	461	Identity:	107/461 - (23%)
Similarity:	190/461 - (41%)	Gaps:	94/461 - (20%)

- Green bases have known domain annotations that are detailed below.

Zfish     5 SWPCTQAYTAFS---ACLLTGCIYSLYDDE-DKDLLIEKNLSQDSPSGRTDDDNVNNEELYST-- 63
            |:|...:|.|.|   |.:.:..:::.:..: :...|||:.|.             ||..|.|.
Worm    26 SFPSVDSYLALSVLVAIVASVTVFTTFRSQPELQKLIEEELR-------------NNTRLSSAYG 77

Zfish    64 ----GLWCHT---------TGSLCMWVLVNTLCCFLLLMGKCIQLVV---FGDLRINEKQNLKDK 112
                .|..||         :.:..:||.:|:   :..::..|.:|::   |.:|...|:...:..
Worm    78 LNIEALSGHTFFQIAHYILSDTTLIWVAINS---YFAILAVCTRLIIKLTFKELARQEENVARQA 139

Zfish   113 TWNFLFNKLIFLFGVLNVRTEREMAMWCLCFSALLFLQLLAQLCKDRFEFLSSSPSSTALGSHMH 177
            .:.::...:::|..|:..:....:..|.:......||..|..:...|.:.:|.|...   ||...
Worm   140 FFCYVLLTIVYLSVVIGPQKGHRVMPWMIWGGICAFLSHLQFITCQRLKHISPSCDR---GSQKI 201

Zfish   178 LLLVLMCLFVSSGGLTIICVLLGFSFGMHTLSF-----MAVECLMVSVYVNHSILRYAIHLYDLM 237
            ..|.|...|||      |.:....|...|.|::     :..:||:       ::.|....|:..:
Worm   202 SFLSLFLFFVS------IAMTFLISRFQHHLTWQPAVLLYFDCLL-------AVFRSTYILFRCI 253

Zfish   238 CDS---SWEGKEV--FIYY----TDFVMEMGILLLDMMHHINMLLYGNVWFSVADLFILTHIRFL 293
            ..|   |:....|  |.|:    |:||.|    |:.|:....:|.: :...::..:|.|.|::..
Worm   254 SSSRVFSFNPDSVRHFNYWLELITNFVCE----LIQMLSFAQLLAF-SPGLNLTSIFFLYHMKLT 313

Zfish   294 AKEMQRKLFQHKNYMHIYDVMDTRFSMATMEELASRDDRCVICWEKMYTAYKLPCGHLFHKSCLR 358
            ...|..:|.:|:|:..|::.::..:...   :.|:.|||||:|||.:.|:.:|||.|.||..||.
Worm   314 YNCMTEQLSRHRNHKKIFEHIERSYPSV---KCANGDDRCVVCWELLGTSRRLPCSHQFHDWCLM 375

Zfish   359 SWLEQNMSCPTCRMSVNMSGGHTGNEQEGALFSLGATDVPSRPPTRYHSQLFHFNGSQIS-NWLP 422
            .||.|:.||||||.::.                 ...|...:||...:|....|||.... ...|
Worm   376 WWLAQDSSCPTCRCTIP-----------------SPQDQIRQPPEVGNSTRLRFNGGSFGFVHFP 423

Zfish   423 GFSVEV 428
            .|::||
Worm   424 AFTLEV 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amfrb	XP_005169066.1	HRD1	77..>403	CDD:227568	80/342 (23%)
amfrb	XP_005169066.1	zf-RING_2	331..371	CDD:290367	23/39 (59%)
hrdl-1	NP_492602.2	HRD1	<200..>407	CDD:227568	63/244 (26%)
		zf-RING_2	348..388	CDD:290367	23/39 (59%)
		CUE_AMFR	449..489	CDD:270604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161032776
Domainoid	1	1.000	65	1.000	Domainoid score	I7252
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I3166
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D271732at33208
OrthoFinder	1	1.000	-	-		FOG0006872
OrthoInspector	1	1.000	-	-		otm13239
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3836
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.900