DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RBM5 and CG4887

DIOPT Version :9

Sequence 1:NP_005769.1 Gene:RBM5 / 10181 HGNCID:9902 Length:815 Species:Homo sapiens
Sequence 2:NP_001259859.1 Gene:CG4887 / 33304 FlyBaseID:FBgn0031318 Length:1004 Species:Drosophila melanogaster


Alignment Length:929 Identity:297/929 - (31%)
Similarity:445/929 - (47%) Gaps:178/929 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     3 SDKRVSRTERSGRYGSIIDRD----DRD--ERESRSRRRDSDYKRSS--DDR-----RGDRYDDY 54
            ||:.::..|...|...:..||    |||  ...||||.....:.|::  |||     |..|:.|:
  Fly   131 SDRELNDYEYEQRSRDLDSRDRSSTDRDWYHNRSRSREHSRPWNRNNNHDDRSRSNERNTRHRDH 195

Human    55 RDYD------SPERERER-RNSDRSEDGYHSDGD-----YGEHDYRHDISDERESK--------- 98
            |.|:      :.:|:|:| |..||..|   .|.|     .|..||..|....|.:|         
  Fly   196 RMYNGGGSNHNRDRDRDRDREQDRERD---RDRDRDRERRGSSDYDSDEGHMRRNKYRSTTEALN 257

Human    99 TIMLRGLPITITESDIREMMESFE-GPQPADVRLMKRK-TGVSRGFAFVEFYHLQDATSWMEANQ 161
            .|::.||...:|.:||  |.|..: ..:||.:|::::: |..|||.|||||..:::|..||:..|
  Fly   258 IIIIFGLTKEMTRADI--MSELIKVNMEPACIRIIRKQGTDSSRGIAFVEFNTVEEAKQWMDITQ 320

Human   162 KKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPGTTESVQSV 226
            ..|.:..:.::|.||:.|  .:||.||||.:.||:.|..||.|...:.|||.....| :|.|..|
  Fly   321 GVLKLNDERVSMRYSHKR--IQDWNCNKCGVCNFKFRFYCFVCKTSREDSETTFSSG-SEGVDEV 382

Human   227 D-YYCDTIILRNIAPHTVVDSIMTALSPY---ASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMDA 287
            . .....|:|||:...|..::::|||..:   .|..|:.:.:.:|..||.:||..::...:.:|:
  Fly   383 STILTKKIMLRNLDALTNEEAVLTALQLHLKDLSKTVSKVLISRDSLTQASRGICYLHFDTLVDS 447

Human   288 SQLLQILQSLHPPLKIDGKTIGVDFA--------------KSARKDLVLSDGNRVSAFSVASTAI 338
            ..:...|.:|.|||.:|.:.:.:.:.              :.|.||..::.|| :||.       
  Fly   448 MNVHNALTALDPPLTLDDRVVAITYCIDLEEQQALPKNPKELAVKDSTVNSGN-ISAV------- 504

Human   339 AAAQWSSTQSQSGEGGS---------VDYS---YLQPGQDGYAQYAQYSQDYQQFYQQQAGGLES 391
                     |.||.||:         .:||   |    ....|::|.|.|.|.::|.........
  Fly   505 ---------SPSGLGGNYTLADVPRLAEYSASLY----ASNPAEHAYYVQYYTEYYTADINKNNR 556

Human   392 DA---SSASGTAVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPST---STSTQAPAASPTGVVP 450
            |:   .:.||.||..  :|:..:..::.:..:....:.|..||.:.   :|.....|::|.| ..
  Fly   557 DSHLTEANSGAAVAL--SAIQRKQKKMSSIETTITAAATAAAQAAAQVKATLAAQVASAPKG-ND 618

Human   451 GTKYAVPDTSTYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAESSSH- 514
            |..|..||.:.|||||:||||||.||||||:.:||||||:.|..|||||..:.|||.|..:|:. 
  Fly   619 GKIYPTPDVTQYQYDETSGYYYDSTTGLYYNAHSQYYYNNETGAYLYWDQRRSTYVLATPASTQA 683

Human   515 ---------QQSGLPPAKEGKEKK---EKPKSKTAQQIAKDMERWAKSLNKQKE-NFKNSFQPV- 565
                     :|.|...:|:.|||:   :..|.|.|::|.||||:|||.||::|: ....:.||: 
  Fly   684 ALQEVLADAEQKGEEESKKAKEKEGGNKHDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATPQPIL 748

Human   566 -NSLREEER-RESAAADAGFALFEKKGALAERQQLIPELVRNGDEENPL---KRGLVAAYSGDSD 625
             |.:....| .:...||.||::.|||    ||.:|      |....||.   ...||.||.|.||
  Fly   749 ANEVATTSRGNQGGYADVGFSILEKK----ERGKL------NDYAPNPTVGPMNKLVNAYGGTSD 803

Human   626 NEEELVERLE-------------SEEEKLADWKKMACLLCRRQFPNKDALVRHQQLSDLHKQNMD 677
            :||:.....:             :||....|:.|:.||||:|.|.:.:.|.:|.::|.|||:|: 
  Fly   804 SEEDNAASSQNTQSSAVVSGGGGAEESDYVDFHKLTCLLCKRAFQSLEILQKHLKMSTLHKENL- 867

Human   678 IYRRSRLSEQELEALELREREMKYRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTKD--- 739
                ::|::....::   |..:.|||||.|||.|||..:||.|.|.::      .:||..|.   
  Fly   868 ----AKLNQNTSSSI---EEALAYRDRAKERRLKYGESDPPPPNRSRE------RFEQEIKTLQS 919

Human   740 ------------GIDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYG 792
                        .|..||:|:::||.|||.||.|||||.||.|..|||..|....|||.| |...
  Fly   920 RQKQSTSATPAMPISSSNVGSRLLQKMGWSEGQGLGRKNQGRTQIIEADGRSNYVGLGNK-SGQM 983

Human   793 LSGADSYKDAVRKAMFARF 811
            :.|.| ||..::|.|..|:
  Fly   984 IPGND-YKSYIKKMMKQRY 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RBM5NP_005769.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..93 35/114 (31%)
RRM 40..>181 CDD:223796 53/170 (31%)
RRM1_RBM5 93..179 CDD:241196 30/96 (31%)
zf-RanBP 181..210 CDD:279035 12/28 (43%)
RanBP2-type Zn finger 185..204 CDD:275375 10/18 (56%)
RRM2_RBM5 229..314 CDD:241199 22/101 (22%)
Required for interaction with U2AF2. /evidence=ECO:0000269|PubMed:18851835 321..809 186/553 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 411..468 16/59 (27%)
Sufficient for interaction with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200. /evidence=ECO:0000269|PubMed:18851835 452..535 44/95 (46%)
OCRE_RBM5 455..510 CDD:293887 35/54 (65%)
OCRE repeat 1 460..467 CDD:293887 4/6 (67%)
OCRE repeat 2 468..475 CDD:293887 6/6 (100%)
OCRE repeat 3 476..483 CDD:293887 5/6 (83%)
OCRE repeat 4 484..491 CDD:293887 6/6 (100%)
OCRE repeat 5 493..500 CDD:293887 4/6 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..540 11/45 (24%)
G-patch 743..787 CDD:279867 25/43 (58%)
CG4887NP_001259859.1 DUF1777 115..>196 CDD:285811 20/64 (31%)
RRM_SF 255..335 CDD:302621 26/81 (32%)
ZnF_RBZ 341..364 CDD:197784 12/22 (55%)
RanBP2-type Zn finger 342..361 CDD:275375 10/18 (56%)
RRM1_RRM2_RBM5_like 387..473 CDD:240759 22/85 (26%)
OCRE_RBM5_like 623..678 CDD:293881 35/54 (65%)
OCRE repeat 1 628..635 CDD:293881 4/6 (67%)
OCRE repeat 2 636..643 CDD:293881 6/6 (100%)
OCRE repeat 3 644..651 CDD:293881 5/6 (83%)
OCRE repeat 4 652..659 CDD:293881 6/6 (100%)
OCRE repeat 5 661..668 CDD:293881 4/6 (67%)
G-patch 935..979 CDD:279867 25/43 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152939
Domainoid 1 1.000 124 1.000 Domainoid score I5526
eggNOG 1 0.900 - - E1_KOG0154
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 371 1.000 Inparanoid score I2130
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55750
OrthoDB 1 1.010 - - D786674at2759
OrthoFinder 1 1.000 - - FOG0002462
OrthoInspector 1 1.000 - - mtm8631
orthoMCL 1 0.900 - - OOG6_102541
Panther 1 1.100 - - O PTHR13948
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1642
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.770

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