Protein Alignment CDK3 and Cdk4

DIOPT Version :9

• Sequence 1: NP_001249.1
• Gene: CDK3 / 1018
• HGNCID: 1772
• Length: 305
• Species: Homo sapiens
• Sequence 2: NP_001286493.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Alignment Length: 296
• Identity: 136/296 - (45%)
• Similarity: 180/296 - (60%)
• Gaps: 13/296 - (4%)

Human     4 FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKEL---KHPNIVR 65
            :|::..||||.||.||:|::..||.:|||||:|:.|...|||.:.:|||||||:|   .|.|||:
  Fly    26 YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVK 90

Human    66 LLDVVH-----NERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIH 125
            |.:|..     .:..:.||||.:.|||...:|..|.|.:....|:....:||.||.|.||||:||
  Fly    91 LYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIH 155

Human   126 RDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIG 190
            |||||||||::..|.:|:||||||:.:|..:: .|..||||||||||:||... |.:.|||||..
  Fly   156 RDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK-LTSVVVTLWYRAPEVLLAQP-YNSTVDIWSAA 218

Human   191 CIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNL 255
            ||..||..|:|||||.||.:||.|||.:.|.|:|..||....:.  ...||:...|..::..|:|
  Fly   219 CIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVA--LEHFPQRHPKRPKDFCPHL 281

Human   256 EPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEP 291
            .....|||.::|.||...|.:|...|.|.||.. ||
  Fly   282 CKYADDLLNKMLSYDLHLRPSALACLEHDYFQQ-EP 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK3	NP_001249.1	PLN00009	1..293	CDD:177649	136/296 (46%)
		STKc_CDK2_3	3..286	CDD:270844	132/289 (46%)
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	132/289 (46%)
		S_TKc	26..312	CDD:214567	132/289 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810