DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBM7 and NGR1

DIOPT Version :9

Sequence 1:	NP_001272974.1	Gene:	RBM7 / 10179	HGNCID:	9904	Length:	267	Species:	Homo sapiens
Sequence 2:	NP_009771.3	Gene:	NGR1 / 852513	SGDID:	S000000416	Length:	672	Species:	Saccharomyces cerevisiae

Alignment Length:	224	Identity:	47/224 - (20%)
Similarity:	95/224 - (42%)	Gaps:	22/224 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    11 TLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQFAFVNFKHEVSVPYAMNLLNGIKL 75
            |:|||.|..|.||..|..||...||::.|:||..|:     ..||.|:..:....::..|.|..:
Yeast   361 TVFVGGLVPKTTEFQLRSLFKPFGPILNVRIPNGKN-----CGFVKFEKRIDAEASIQGLQGFIV 420

Human    76 YGRPIKIQF-RSGSSHAPQDVSLSYPQHHVGNSSPTSTSPSSRYERTMDNMTSSAQIIQRSFSSP 139
            .|.||::.: |..||:|..:.::.....::.::...:.|.:|..:.:...:...|:..:|.|...
Yeast   421 GGSPIRLSWGRPSSSNAKTNSTIMGASQYMSSNGLRAPSAASSVDNSKQILEQYAEDKRRLFLHQ 485

Human   140 ENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMN 204
            :..|:|        |....|.|....:..:.:        :::|.....:.:.|:.|....::.:
Yeast   486 QQQQQQ--------QQQQDGNFSMEQMAHNNY--------YNYNNYDYHRNKNGSHSDLVNLQRS 534

Human   205 SYPYLADRHYSREQRYTDHGSDHHYRGKR 233
            :.||:.:.......:|:......|..|.:
Yeast   535 NVPYMQEDGALYPHQYSSPSYSLHPTGNQ 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM7	NP_001272974.1	RRM	<9..>84	CDD:223796	25/72 (35%)
		RRM_RBM7	9..83	CDD:241036	25/71 (35%)
		ZCCHC8 binding. /evidence=ECO:0000269\|PubMed:27905398, ECO:0007744\|PDB:5LXR, ECO:0007744\|PDB:5LXY	25..35		3/9 (33%)
		ZCCHC8 binding. /evidence=ECO:0000269\|PubMed:27905398, ECO:0007744\|PDB:5LXR, ECO:0007744\|PDB:5LXY	59..76		2/16 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..267		8/71 (11%)
NGR1	NP_009771.3	RRM1_NGR1_NAM8_like	35..180	CDD:410023
		RRM2_NGR1_NAM8_like	191..270	CDD:410025
		RRM	<308..526	CDD:223796	41/185 (22%)
		RRM3_NGR1_NAM8_like	359..430	CDD:409782	25/73 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910