Protein Alignment RBM7 and B52

DIOPT Version :10

• Sequence 1: NP_001272974.1
• Gene: RBM7 / 10179
• HGNCID: 9904
• Length: 267
• Species: Homo sapiens
• Sequence 2: NP_788671.2
• Gene: B52 / 41670
• FlyBaseID: FBgn0004587
• Length: 355
• Species: Drosophila melanogaster
• Alignment Length: 260
• Identity: 67/260 - (25%)
• Similarity: 95/260 - (36%)
• Gaps: 58/260 - (22%)

Human    12 LFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQFAFVNFKHEVSVPYAMNLLNGIKLY 76
            |.|.||.::|:.:.|.:...|||.|......|.:    :....|.|.....:..|:..|:..:|.
  Fly   122 LIVENLSSRVSWQDLKDYMRQAGEVTYADAHKQR----RNEGVVEFASLSDMKTAIEKLDDTELN 182

Human    77 GRPIKI--QFRSGSSHAPQDVSLSYPQHHVGNSSPTSTSPSSRYERTMDNMTSSAQIIQRSFSSP 139
            ||.|.:  ..|.|.|....           |:....|.|.|||         |.::..:||.|..
  Fly   183 GRRIHLVEDRRGGRSGGGG-----------GSGRGRSRSSSSR---------SRSRSRRRSRSRR 227

Human   140 ENFQRQAVMNSALRQMSYGGKFGS-SPLDQSGFSPSVQSHSHSFNQSSS---SQWRQGTPSSQRK 200
            .:..|.   .|..|..|.||:..| ||:.....|.|..:.|...::|.|   |:.|..:|..:|.
  Fly   228 SSHSRS---KSRSRSKSRGGRSKSKSPVKSRSRSRSRSNKSRDVSKSKSKSHSRTRSRSPKRERD 289

Human   201 VRMNSYPYLADRHYS-REQRYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRS 264
            .|..|      |..| ||.|........|    ||     .|:.|         |.:|.:.|.||
  Fly   290 SRSRS------RSVSKRESRSRSRSKSIH----RD-----SRSRD---------RSASAENKSRS 330

Human   265  264
              Fly   331  330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBM7	NP_001272974.1	RRM_RBM7	9..83	CDD:410005	19/72 (26%)
		ZCCHC8 binding. /evidence=ECO:0000269|PubMed:27905398, ECO:0007744|PDB:5LXR, ECO:0007744|PDB:5LXY	25..35		3/9 (33%)
		ZCCHC8 binding. /evidence=ECO:0000269|PubMed:27905398, ECO:0007744|PDB:5LXR, ECO:0007744|PDB:5LXY	59..76		2/16 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..267		29/107 (27%)
B52	NP_788671.2	RRM1_SRSF4_like	5..74	CDD:409774
		RRM2_SRSF4_like	120..191	CDD:410012	19/72 (26%)