DRSC/TRiP Functional Genomics Resources

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Protein Alignment RBM7 and Hrb27C

DIOPT Version :10

Sequence 1:NP_001272974.1 Gene:RBM7 / 10179 HGNCID:9904 Length:267 Species:Homo sapiens
Sequence 2:NP_476869.1 Gene:Hrb27C / 33968 FlyBaseID:FBgn0004838 Length:421 Species:Drosophila melanogaster


Alignment Length:314 Identity:63/314 - (20%)
Similarity:108/314 - (34%) Gaps:105/314 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    12 LFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQ-FAFVNFKHEVSVPYAMNLLNGIKL 75
            :|:|.|.:.|||..|...|::.|.|.:|.|..|::.|..: |.|::|:.|.||.:..| ...|.|
  Fly    98 VFLGGLPSNVTETDLRTFFNRYGKVTEVVIMYDQEKKKSRGFGFLSFEEESSVEHVTN-ERYINL 161

Human    76 YGRPIKI---QFRSGSS--------------------------HAPQDV-----------SLSYP 100
            .|:.::|   :.|.||.                          |||.::           .|:.|
  Fly   162 NGKQVEIKKAEPRDGSGGQNSNNSTVGGAYGKLGNECSHWGPHHAPINMMQGQNGQMGGPPLNMP 226

Human   101 --------------------QHHVGNSSPTS----------TSPSSRYERTMDNMTSSAQIIQRS 135
                                |:..|||.|.|          ..|..::.               :
  Fly   227 IGAPNMMPGYQGWGTSPQQQQYGYGNSGPGSYQGWGAPPGPQGPPPQWS---------------N 276

Human   136 FSSPENFQ-------RQAVMNSALRQMSYGGKFGS--SPLDQSG--FSPSVQSHSHSFNQSSSSQ 189
            ::.|:..|       ..:....|....|.||.:.|  .|.:.:|  .:|...:.:.:...|.:..
  Fly   277 YAGPQQTQGYGGYDMYNSTSTGAPSGPSGGGSWNSWNMPPNSAGPTGAPGAGAGTATDMYSRAQA 341

Human   190 WRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDRNH 243
            |..|.||:...|  ...|.....:.:.:.     ||::.|.|....:.|:..|:
  Fly   342 WATGGPSTTGPV--GGMPRTGPGNSASKS-----GSEYDYGGYGSGYDYDYSNY 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RBM7NP_001272974.1 RRM_RBM7 9..83 CDD:410005 25/74 (34%)
ZCCHC8 binding. /evidence=ECO:0000269|PubMed:27905398, ECO:0007744|PDB:5LXR, ECO:0007744|PDB:5LXY 25..35 2/9 (22%)
ZCCHC8 binding. /evidence=ECO:0000269|PubMed:27905398, ECO:0007744|PDB:5LXR, ECO:0007744|PDB:5LXY 59..76 5/16 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 163..267 17/85 (20%)
Hrb27CNP_476869.1 RRM1_hnRNPA_hnRNPD_like 9..80 CDD:409763
RRM2_DAZAP1 94..173 CDD:409765 25/75 (33%)
Blue background indicates that the domain is not in the aligned region.

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