Protein Alignment CG42818 and CACNA2D4

DIOPT Version :10

• Sequence 1: NP_001188821.1
• Gene: CG42818 / 10178877
• FlyBaseID: FBgn0262000
• Length: 1085
• Species: Drosophila melanogaster
• Sequence 2: NP_758952.4
• Gene: CACNA2D4 / 93589
• HGNCID: 20202
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 107/580 - (18%)
• Similarity: 196/580 - (33%)
• Gaps: 174/580 - (30%)

  Fly   609 HDFKDQINDDDSKSLKHLIKILSDLVYSLNDKNN-IKSTSQLTTESTFNSSINITNSTTVASSTF 672
            |:|.:.:..|...|:         |:...::|.| ::..::...||..:.| |:..:|:::|...
Human   155 HEFNESLVFDYYNSV---------LINERDEKGNFVELGAEFLLESNAHFS-NLPVNTSISSVQL 209

  Fly   673 ST---TESMAIHSTPYLSTREITVFQFNDVENINPIISNNSTTVTTNIHSSTYTTSTTDNTTSYP 734
            .|   .:...|.:..|:|.....||    |||.     ....|:|..     |..|.|.....||
Human   210 PTNVYNKDPDILNGVYMSEALNAVF----VENF-----QRDPTLTWQ-----YFGSATGFFRIYP 260

  Fly   735 NLSTTESSP---TFDSTISHSNTSSQTRSLGSYKDKIKNIVELLKKLRKIQKTLADKSKGQLSPM 796
            .:..|....   |||.    .|.....::..|.|| |..:|::...::.::.|:|   |..::.:
Human   261 GIKWTPDENGVITFDC----RNRGWYIQAATSPKD-IVILVDVSGSMKGLRMTIA---KHTITTI 317

  Fly   797 LISRIKAVLKQIVAGNIDSVNGDSTELEILLSTTVNPNEDTTDLTMEKL---------------- 845
            |.:..:.....|:|.| |.|:......:.:|......|.:...|.:|:|
Human   318 LDTLGENDFINIIAYN-DYVHYIEPCFKGILVQADRDNREHFKLLVEELMVKGVGVVDQALREAF 381

  Fly   846 --LKLF---------------------DDFE-------------RMYNVLL--DDSIQSTTQSTT 872
              ||.|                     :|:|             |::..|:  :.|.....:...
Human   382 QILKQFQEAKQGSLCNQAIMLISDGAVEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWIA 446

  Fly   873 QNNTIFSTTYSTIFSTTQSISTTSPTQYALTSSTPNTSTTSH--------------SSTPSSINN 923
            .||..:.|..||:..|.:::     .:|....|.|......|              ||...|:..
Human   447 CNNKGYYTQISTLADTQENV-----MEYLHVLSRPMVINHDHDIIWTEAYMDSKLLSSQAQSLTL 506

  Fly   924 L---------RSDESNNHQPIVDAI-------QQLKMALYHDF----YAFKKSQEERMEKILQLL 968
            |         :.:|:.:|..::..:       :.:|:|..:..    |||           |...
Human   507 LTTVAMPVFSKKNETRSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAF-----------LNTN 560

  Fly   969 NG--------KPIDRRTKTIAKPRTIRKKVSREIQKRNSDVK-EDKIHHYKADKFIKNPKNGNQD 1024
            ||        :|:.|..|.: ||:.....|..      |:|: ||:....:....  |.:.|...
Human   561 NGYILSHPDLRPLYREGKKL-KPKPNYNSVDL------SEVEWEDQAESLRTAMI--NRETGTLS 616

  Fly  1025 SHIPKPILNSAR----------SKIKDVPLKLSAIKVNGGLKHLPSKRKANEEVSAMHEI 1074
            ..:..|:....|          :.|.|.|..|..:...|..:::.....:.||  .:|::
Human   617 MDVKVPMDKGKRVLFLTNDYFFTDISDTPFSLGVVLSRGHGEYILLGNTSVEE--GLHDL 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42818	NP_001188821.1	None
CACNA2D4	NP_758952.4	VWA_N	148..264	CDD:462464	29/132 (22%)
		vWA_VGCC_like	277..460	CDD:238740	33/187 (18%)
		MIDAS-like motif	297..301		0/3 (0%)
		HK_sensor	<484..537	CDD:365792	6/52 (12%)
		HK_sensor	539..654	CDD:365792	26/134 (19%)
		VGCC_alpha2	661..1110	CDD:462488	3/16 (19%)