DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42818 and CACNA2D2

DIOPT Version :9

Sequence 1:	NP_001188821.1	Gene:	CG42818 / 10178877	FlyBaseID:	FBgn0262000	Length:	1085	Species:	Drosophila melanogaster
Sequence 2:	XP_011532545.1	Gene:	CACNA2D2 / 9254	HGNCID:	1400	Length:	1151	Species:	Homo sapiens

Alignment Length:	1109	Identity:	172/1109 - (15%)
Similarity:	320/1109 - (28%)	Gaps:	447/1109 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RKPMDKDPRNPLKRLKFLQEFPTQSSKGDLDDLKYPTQLEGRHDSPKYDKTFHTEIHANNETDSQ 92
            |:|....|| ||..|  |...|..::.| .....:|.|              ||..|.....: |
Human    34 RRPTSGPPR-PLWLL--LPLLPLLAAPG-ASAYSFPQQ--------------HTMQHWARRLE-Q 79

  Fly    93 ELENII--------LEKNLQDSKT--EFQENRASQPKNMHSFQIPEAIESHFNNK--ELQNENDL 145
            |::.::        |.:..:|::.  |.|||   :|:.:.. ::...|||..:.|  .|:...|.
Human    80 EVDGVMRIFGGVQQLREIYKDNRNLFEVQEN---EPQKLVE-KVAGDIESLLDRKVQALKRLADA 140

  Fly   146 HKGLKQQYRSGSEQDKSGPENVREIASKLILQWAENQRSLLDSFVKAITDVLK-VHDSKLNMKIN 209
            .:..::.:|   .||....|::....:|...:..:.:...::...||.|..|. :.|.....|:|
Human   141 AENFQKAHR---WQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVN 202

  Fly   210 ISPRDIMILKDMLKQLLESIMQLREGSTSTRARIVLNK--WIETQKSLIDSFSQAIQNTNQNVDN 272
            .|...:.|..|:.|           |||     ::||:  |.|..:::.      ::|..|:...
Human   203 YSYAAVQIPTDIYK-----------GST-----VILNELNWTEALENVF------MENRRQDPTL 245

  Fly   273 IANVYEVMENLNK-----------------------------NLRELVILLSDKESFPTTESSSS 308
            :..|:.....:.:                             :.:::||::.       ...|.|
Human   246 LWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVD-------VSGSVS 303

  Fly   309 QQTTSIYATTTF----------YLTSSTFGS--------THPIVDENINRVNIMGNLIKGLRNIM 355
            ..|..:..|:..          |:..::|..        || :|..|:....:....::|:
Human   304 GLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTH-LVQANVRNKKVFKEAVQGM---- 363

  Fly   356 VQMDETNKTSSSTSYTT-TESTYIQPSTSTYLNAEVTTSHPTTSTYEVTNIITD--ESKIKDMFN 417
                   ....:|.|.. .|..:.|...|....|...         ::..:.||  |.:::|:|
Human   364 -------VAKGTTGYKAGFEYAFDQLQNSNITRANCN---------KMIMMFTDGGEDRVQDVF- 411

  Fly   418 LIKGIEDLISQYN-------------GKHKFTST------------------------------- 438
                     .:||             |:|.:..|
Human   412 ---------EKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLD 467

  Fly   439 -----TSLTGKSNSREPTMTTYSSAGGITSHSFTTTSPKTVTTSSSHSTTESSPSHPTTSNYEVT 498
                 ..|.||...:......|..|.|:   ....|.     |....:.|:..|..
Human   468 VLGRPMVLAGKEAKQVQWTNVYEDALGL---GLVVTG-----TLPVFNLTQDGPGE--------- 515

  Fly   499 VFDQDSHKFKVMKN-LIKELKGLIEHFSDTKNITSTTYSTG--------DSKSFQPTATTPDSTD 554
                       .|| ||..:.|:....:|.|.:| ..|:.|        |...:
Human   516 -----------KKNQLILGVMGIDVALNDIKRLT-PNYTLGANGYVFAIDLNGY----------- 557

  Fly   555 RSSSQPITFPESTTSTTNLQSTITNHLSTESTSSQLNTTLSITGTTTPNLTTSTHDFKD-QINDD 618
                 .:..|.....|||.:..:                              |.||.| ::.|:
Human   558 -----VLLHPNLKPQTTNFREPV------------------------------TLDFLDAELEDE 587

  Fly   619 DSKSLKHLI-------KILSDLVYSLNDKNNIKSTSQLTTESTFNSSINITNSTTVASSTFSTTE 676
            :.:.::..:       |.:..||.||::    :...::|...|:         ..:.|:.:|...
Human   588 NKEEIRRSMIDGNKGHKQIRTLVKSLDE----RYIDEVTRNYTW---------VPIRSTNYSLGL 639

  Fly   677 SMAIHSTPYLSTR--------EITVFQFNDVENINPIISNNSTTVTTNIHSSTYTTSTTDNTTSY 733
            .:..:||.||...        ::.:.:..|.|.:.|....:...|...........:.:||.|.:
Human   640 VLPPYSTFYLQANLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPREYCKDLNASDNNTEF 704

  Fly   734 PNLSTTESSPTFDSTISHSNTSSQTRSLGSYKDKIKNIVELLKKLRKIQKTLADKSKGQLSPMLI 798
                                              :||.:||::|
Human   705 ----------------------------------LKNFIELMEK--------------------- 714

  Fly   799 SRIKAVLKQIVAGNIDSVNGDSTELEILLSTTVNPNEDTTDLTMEKLLKLFDDFERMYNVLLDDS 863
                             |..||.:....|                           ::|::||..
Human   715 -----------------VTPDSKQCNNFL---------------------------LHNLILDTG 735

  Fly   864 I-QSTTQSTTQNNTIFSTTYS--TIFSTTQSISTTSPTQYALTSSTPNTSTTSHSSTPSSIN-NL 924
            | |...:...::..:  .|||  .:|:.|..         .:|...||.:....:..|...| :.
Human   736 ITQQLVERVWRDQDL--NTYSLLAVFAATDG---------GITRVFPNKAAEDWTENPEPFNASF 789

  Fly   925 RSDESNNHQPIVDAIQQLKMALYHDFYAFKKSQEERMEKILQLLN---GKPIDRRTKTIAKPRTI 986
            .....:||.                 |.||...::.:.:.|:|.|   |..:....:.....||:
Human   790 YRRSLDNHG-----------------YVFKPPHQDALLRPLELENDTVGILVSTAVELSLGRRTL 837

  Fly   987 RKKV 990
            |..|
Human   838 RPAV 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42818	NP_001188821.1	PHA03255	642..>763	CDD:165513	15/128 (12%)
CACNA2D2	XP_011532545.1	VWA_N	141..265	CDD:285584	26/148 (18%)
		vWA_VGCC_like	277..456	CDD:238740	29/216 (13%)
		Cache_1	485..573	CDD:280839	22/132 (17%)
		VGCC_alpha2	580..663	CDD:285647	15/95 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900