Protein Alignment CG42818 and cacna2d1a

DIOPT Version :9

• Sequence 1: NP_001188821.1
• Gene: CG42818 / 10178877
• FlyBaseID: FBgn0262000
• Length: 1085
• Species: Drosophila melanogaster
• Sequence 2: XP_009298560.1
• Gene: cacna2d1a / 561434
• ZFINID: ZDB-GENE-041210-215
• Length: 1093
• Species: Danio rerio
• Alignment Length: 804
• Identity: 145/804 - (18%)
• Similarity: 260/804 - (32%)
• Gaps: 232/804 - (28%)

  Fly   247 KWIETQK----SLIDSFSQAIQNTNQNVDNIANVYEVMENLNKNLRELVILLSDKESFPTTESSS 307
            ||.|..:    .||||.| .|:...:..:|....|.|.:|   |.|:||            |.:|
Zfish    39 KWAEKMQEDLVQLIDSES-GIKELKKIFNNFQRHYTVRQN---NPRQLV------------EKAS 87

  Fly   308 SQQTTSIYATTTFYLTSSTFGSTHPIVDENINRVNIMGNLIKGLRNIM--------VQMDET--- 361
                                   |.|.:...||...:..|.....|:.        :.::||
Zfish    88 -----------------------HEIEEFLANRSKALEALATAAENLQKEHQWKEDLDVNETIYY 129

  Fly   362 NKTSSSTSYTTTESTYI------QPSTSTYLNAEVTTSHPTTSTYEVTNIITDESKIKDMFNLIK 420
            |....|.:.|......:      .|:....::...|..|..|..||.:.||.:|      .|...
Zfish   130 NAKDKSDNQTEPRKNRLILDFTEDPAFKRPVSYNTTAVHIPTDIYEGSTIILNE------LNWTA 188

  Fly   421 GIEDLISQYNGKHKFTSTTSLTGKSNSREPTM--TTYSSAGGITSHSFTTTSPKTVTTSSSHSTT 483
            .::|:..                |:...:|::  ..:.||.|:..:
Zfish   189 ALDDVFR----------------KNKEDDPSLHWQVFGSATGLARY------------------- 218

  Fly   484 ESSPSHP-TTSNYEVTVFDQDSHKFKVMKNLI-KELKGLIEHFSDTKNITSTTYSTGDSKSFQPT 546
              .|:.| ..|..::.::|.....:.:..... |::..|::.......:|.....|..|:..:..
Zfish   219 --FPASPWVDSKNKIDLYDVRRRPWYIQGAASPKDMLILVDASGSVSGLTLKLIRTSVSEMLETL 281

  Fly   547 ATTPDSTDRSSSQPITFPESTTSTTNLQSTITNHLSTESTSSQLNTTLSITGTTTPNLTTSTHDF 611
                  :|......::|..|..|....::.:..::..:.|..:....::..|||...:     .|
Zfish   282 ------SDDDYVNIVSFNNSAKSVACFENLVQANVRNKKTLKEAVQKITANGTTDYKI-----GF 335

  Fly   612 KDQINDDDSKSLKH-----LIKILSDLVYSLNDKNNIKSTSQLTTESTFNSSINITNSTTVASST 671
            |:..|...|.::..     :|.:.:|   ...||     .|::..|...:..:.|        .|
Zfish   336 KEAFNQLASMNVSRANCNKIIMLFTD---GGEDK-----ASEIFDEYNSDKRVRI--------FT 384

  Fly   672 FST---------TESMAIHS------TPYLSTREITVFQFNDVENINPIISNNSTTVT---TNIH 718
            ||.         .:.||.|:      .|.:....|...::.||.. .|::..:.....   ||::
Zfish   385 FSVGQHNYDKAPIQYMACHNKGYYYEIPSIGAIRINTQEYLDVLG-RPMVKADKKAKNVQWTNVY 448

  Fly   719 SSTYTTSTTDNTTSYPNLSTTESSPTFDSTISHSNTSSQTRSLGSYKDKIKNI--VELLKKLRKI 781
            ......          .|..|.:.|.|:.|    .||.:       |.|.||:  .:::..:..|
Zfish   449 VDALEL----------GLVVTGTLPVFNKT----RTSKE-------KPKGKNLGPSQMILGVMAI 492

  Fly   782 QKTLADKSKGQLSPMLISRIKAVLKQIVAGNIDSVNGDSTELE----ILLSTTVNPNE------- 835
            ..:|.|             ||.:......|    .||....::    :||...:.|.:
Zfish   493 DVSLDD-------------IKRLTPHYTLG----PNGYYFAIDPNGYVLLHPNLQPKDLKSQEPV 540

  Fly   836 --DTTDLTMEKLLKLFDDFERMYNVLLD---DSIQSTTQSTTQNNTI----FST-TYSTIFSTTQ 890
              |..|..||..:|:  |..|.   ::|   ..|:..|...:|:...    |.| |:|.:.....
Zfish   541 TLDFLDAEMEDEVKV--DIRRS---MIDGERSQIRFHTLMKSQDERYIDKGFRTYTWSPVTDADY 600

  Fly   891 SISTTSPTQYALTSSTPNTSTTSHSSTPSSINNLRSDESNNHQPIVDAIQQLKMALY--HDFYAF 953
            |::...| .|:::........|...:....:.||...||..    ||..::....|.  .|:...
Zfish   601 SLALVLP-DYSMSYIKATIGDTITQAKSWILENLAVSESLQ----VDKFEEYGYTLIAPRDYCED 660

  Fly   954 KKSQEERMEKILQLLNGKPIDRRT 977
            .|:|.|.|.:.|...| :.||.:|
Zfish   661 LKAQNENMTQFLIDFN-EYIDVKT 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42818	NP_001188821.1	PHA03255	642..>763	CDD:165513	23/138 (17%)
cacna2d1a	XP_009298560.1	VWA_N	110..224	CDD:285584	23/156 (15%)
		vWFA	237..415	CDD:294047	31/204 (15%)
		Cache_1	444..532	CDD:280839	23/125 (18%)
		VGCC_alpha2	545..627	CDD:285647	18/87 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900