DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42818 and CG4587

DIOPT Version :9

Sequence 1:	NP_001188821.1	Gene:	CG42818 / 10178877	FlyBaseID:	FBgn0262000	Length:	1085	Species:	Drosophila melanogaster
Sequence 2:	NP_001188817.2	Gene:	CG4587 / 34921	FlyBaseID:	FBgn0028863	Length:	1271	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	163/992 - (16%)
Similarity:	327/992 - (32%)	Gaps:	275/992 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FIHQREQLP--------------------FKHNEQDPNYLAPVIQKRKPMDKDPRNPLK----RL 42
            |:.:.|:||                    .|...|...:|.|:.|..  :::||....:    ..
  Fly   157 FMRRFERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNN--LEQDPALSWQYFGSST 219

  Fly    43 KFLQEF-----PTQSSKGD--LDDLKYPTQLEGRHDSPK----------------YDKTFHTEIH 84
            .||:.|     |.:.|||.  :.|.:..........|||                :|....|..:
  Fly   220 GFLRRFPGTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFN 284

  Fly    85 ANNETDSQELENIILEKNLQDSKTEFQENR--ASQPKNMHSFQIPEAIESHFNNKELQNENDLHK 147
            ..:.....:..|:|....:..:.....::|  .:.|.|:      :.|:|.....:||:..:...
  Fly   285 ILDTLGEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNI------QEIKSAVKAIKLQDTANFTA 343

  Fly   148 GLKQQYRSGSEQDKSGPENVREIASKLILQ-WAENQRSLLDSF------VKAITDVL-------- 197
            ||:..:....:.::||..:....|..||.: .:|:.:.::..:      |:..|.::
  Fly   344 GLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRS 408

  Fly   198 KVHDSKLNMK---INISPRDIMILKDMLKQLLESIMQLREGSTSTRARIV--------------- 244
            .:||...:.|   :.|:..|     :..:::::..:.:      .|..|:
  Fly   409 NLHDMACSNKGFFVQINDYD-----EARRKVIDYALVM------ARPMIMYQADHPVHWSPVFVA 462

  Fly   245 -----LNKWIETQKSLIDSFSQAIQNTNQNVDNIANVYEVM---------------ENLNKNLRE 289
                 |.:..|.|:.|:.:.|..:.:...:...:||:..|:               ..|..|...
  Fly   463 GKSGGLGRDSEYQRRLVTTVSTPVFDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYS 527

  Fly   290 LVI-----LLSDKESFPTTESSS-SQQTTSIYAT---TTFYLTSSTFGSTHPIVDENINRVNIM- 344
            .::     :|...:..|..:::. ..|....||:   |...|..:.||:.:..::.|.|.:|.|
  Fly   528 FIVDNNGRVLYHPDLRPLGDANQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKNLLNEMR 592

  Fly   345 GNLIKGLR-----NIMVQMDETNKTSSSTS---YTTTESTYIQPSTSTYLNAEVTTSHPTTSTYE 401
            |::||...     .:|...|::.:.|:.|.   |...|.|   |.|...:..|...||...|..|
  Fly   593 GDMIKPKEGETEFTVMNHYDDSKRVSTRTHRYFYGPIEDT---PFTLAIVLPEKYGSHEFVSQQE 654

  Fly   402 V---TNIITDESK----------IKDMFNLIKGIE---DLISQYNGKHK-------------FTS 437
            :   .|.:|:..|          :...:|.:..:|   :...:|:.:.:             |.|
  Fly   655 IRHSRNNVTEYFKGDNWRVHPDWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLS 719

  Fly   438 TTSLTG------KSNSREPTMTTYSSAGG---------ITSHSFTTTSPKT-------------- 473
            .....|      :..|.:|....:|.:.|         .:.|..:..|.|.
  Fly   720 RAGRPGWKWMSVRPKSPQPHHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLV 784

  Fly   474 ----VTTSSSHSTTESS----PSHPTTSNYEVTVFDQDSHKFKVMKNLIKELKGLIEHFSDTKNI 530
                ||.....:||.||    ..||..:...: :..|...||.|..:.:....||:......|..
  Fly   785 RDAMVTDGLDRNTTGSSSGKEDKHPIATLMAI-LKRQGYQKFVVATSFVATRSGLLRWIDHVKRP 848

  Fly   531 TST--TYSTGDSKSFQPTATTPDSTDRSSSQPITF------------PESTTSTTNLQSTITNHL 581
            ..|  .:.:.|:.....|:....:.|:.|.:|.:|            ..:.|..|...:....|.
  Fly   849 EDTPEPHFSEDNVRAMDTSWYKRAIDQHSVEPDSFVYSVPFGSGYAIKSNATLVTASHAIFVEHR 913

  Fly   582 STESTSSQ--------------LNTTLSITGTTTPNLTTSTHDFKDQINDDD-----SKSLKHLI 627
            ..::.:..              :|.|.:.||.|....|.::.:....:.|:.     |:.::|..
  Fly   914 GHKAAAGVVGLQFQHDSLAKHFINITSACTGMTGCKRTCASDNLDCYVLDNSGFVIISEEMEHTG 978

  Fly   628 K------------ILSDLVY---SLNDKNNIKSTSQLTTESTFNSSINIT----------NSTTV 667
            |            ::.|.:|   ::||...:.|.:    ::.:.::..|.          |....
  Fly   979 KFFGQIDGTIMDSLVQDRIYKRVTVNDYQGVCSDA----DNPYTAAGGILKPNRLGSWFFNHLLA 1039

  Fly   668 ASSTFSTTESMAIHSTP---YLSTREITVFQFNDVENINPIISNNSTTVTTNIH-SSTYTTSTTD 728
            .|:.:.:....::.:.|   |....|..||..|:..:.....:.|...:..:.. ...:||:..:
  Fly  1040 LSAAWLSLMPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVE 1104

  Fly   729 NTTSYPNLSTTESSPTF 745
            .||..|........|.|
  Fly  1105 YTTPPPRQHKPHVGPRF 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42818	NP_001188821.1	PHA03255	642..>763	CDD:165513	18/118 (15%)
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	14/74 (19%)
		vWA_VGCC_like	245..428	CDD:238740	28/188 (15%)
		Cache_1	456..544	CDD:280839	11/87 (13%)
		VGCC_alpha2	590..>647	CDD:285647	14/59 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	0	0.000