Protein Alignment CG42818 and Cacna2d3

DIOPT Version :9

• Sequence 1: NP_001188821.1
• Gene: CG42818 / 10178877
• FlyBaseID: FBgn0262000
• Length: 1085
• Species: Drosophila melanogaster
• Sequence 2: NP_033915.1
• Gene: Cacna2d3 / 12294
• MGIID: 1338890
• Length: 1091
• Species: Mus musculus
• Alignment Length: 615
• Identity: 111/615 - (18%)
• Similarity: 191/615 - (31%)
• Gaps: 179/615 - (29%)

  Fly   347 LIKGLRNIMVQMDETNKTSSSTSYTTTESTYIQPSTSTYLNAEVTTSHPTTSTYEVTNIITDESK 411
            |:|.|..||.:|......:........|..:::......|.            ||..|.:....:
Mouse    87 LVKKLAKIMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQ------------YEYFNAVLINER 139

  Fly   412 IKDMFNLIKGIEDLISQYNGKHKFTSTTSLTGKSNSREPTMTTYSSAGGITSHSFTTTSPKTVTT 476
            .||...|..|.|.:::..:..:......||   |:.:.|| ..|:....|.:..:.:.|...|..
Mouse   140 DKDGNFLELGKEFILAPNDHFNNLPVNISL---SDVQVPT-NMYNKDPAIVNGVYWSESLNKVFV 200

  Fly   477 SSSHSTTESSPSHPTTSNYEVTVFDQDS----HKFKVMKNLIKELKGLIEHFSDTKNITSTTYST 537
            .:                     ||:|.    ..|...|...::..| |:...|...:.:  :..
Mouse   201 DN---------------------FDRDPSLIWQYFGSAKGFFRQYPG-IKWEPDENGVIA--FDC 241

  Fly   538 GDSKSFQPTATTPDSTDRSSSQPITFPESTTSTTNLQSTITNHLSTESTSSQLNTTLS------- 595
            .:.|.:...||:|...       :...:.:.|...|:.||     .:.|.|.:..||.
Mouse   242 RNRKWYIQAATSPKDV-------VILVDVSGSMKGLRLTI-----AKQTVSSILDTLGDDDFFNI 294

  Fly   596 -------------ITGTTTPNLTTSTHDFKDQINDDDSKSLKHLIKILSDLVYSLNDKNNIKSTS 647
                         :.||......|:...|::.::       |...|.:..|..:||:..||.|..
Mouse   295 ITYNEELHYVEPCLNGTLVQADRTNKEHFREHLD-------KLFAKGIGMLDIALNEAFNILSDF 352

  Fly   648 QLTTESTFNSSINITNSTTVASSTFSTTESMAIHSTP--------YLSTREITVFQ--------- 695
            ..|.:.:..|.. |...|..|..|:.|.  .|.::.|        ||..||.....
Mouse   353 NHTGQGSICSQA-IMLITDGAVDTYDTI--FAKYNWPDRKVRIFTYLIGREAAFADNLKWMACAN 414

  Fly   696 ---FNDVENINPIISN--------NSTTVTTNIHSSTYTTSTTDNTTSYPN---------LSTTE 740
               |..:..:..:..|        :...|....|...:|.:..|:|.....         |.||.
Mouse   415 KGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLADDQGLVLMTTV 479

  Fly   741 SSPTFDSTISHSNTSSQTRSLGSYKDKIKN---IVELLKKLRKIQ-------------------- 782
            :.|.|       :..::|||.|.....:..   :.||||.:.|.:
Mouse   480 AMPVF-------SKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHP 537

  Fly   783 --KTLADKSKGQLSPMLISRIKAVLKQIVAGNIDSVNGDSTELE----ILLSTTVNPNEDTTDLT 841
              :.|.::.|.:..|                |..||:....|.|    :|.:..|  |..|...:
Mouse   538 ELRPLYEEGKKRRKP----------------NYSSVDLSEVEWEDRDDVLRNAMV--NRKTGKFS 584

  Fly   842 MEKLLKLFDDFERMYNVLLDDSIQSTTQST 871
            || :.|..|..:|:. |:.:|...:..:.|
Mouse   585 ME-VKKTVDKGKRVL-VMTNDYYYTDIKGT 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42818	NP_001188821.1	PHA03255	642..>763	CDD:165513	31/157 (20%)
Cacna2d3	NP_033915.1	VWA_N	113..229	CDD:285584	26/153 (17%)
		vWA_VGCC_like	242..425	CDD:238740	38/204 (19%)
		MIDAS-like motif	262..266		0/3 (0%)
		Cache_1	452..548	CDD:280839	18/102 (18%)
		VGCC_alpha2	561..633	CDD:285647	14/56 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900