DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42818 and Cacna2d1

DIOPT Version :9

Sequence 1:	NP_001188821.1	Gene:	CG42818 / 10178877	FlyBaseID:	FBgn0262000	Length:	1085	Species:	Drosophila melanogaster
Sequence 2:	XP_011248046.1	Gene:	Cacna2d1 / 12293	MGIID:	88295	Length:	1110	Species:	Mus musculus

Alignment Length:	687	Identity:	129/687 - (18%)
Similarity:	228/687 - (33%)	Gaps:	227/687 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SSKGDLDDLKYPTQLEGRHDSPKY--DKTF-------HTEIHANNETDSQELENIIL-EKNLQDS 106
            ::|.|||..:..::...:...|.:  |..|       |..:|.  .||..|...|:| |.|...:
Mouse   126 NAKDDLDPERNESEPGSQRIKPVFIEDANFGRQISYQHAAVHI--PTDIYEGSTIVLNELNWTSA 188

  Fly   107 KTE-FQENRASQPKNM-HSFQIPEAIESHF------NNKELQNENDLHKGLKQQ-YRSGSEQ--- 159
            ..| |:.||...|..: ..|.....:..::      :|....|:.||:...::. |..|:..
Mouse   189 LDEVFKRNRDEDPTLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKD 253

  Fly   160 -----DKSGPENVREIASKLILQWAENQRSLLDSFVKAITDVLKVHDSKLNMK----------IN 209
                 |.||  :|..:..|||       |:.:...::.::|...|:.:..|..          :.
Mouse   254 MLILVDVSG--SVSGLTLKLI-------RTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQ 309

  Fly   210 ISPRDIMILKDML-------------------KQLL----------ESIMQLREGSTSTRARIVL 245
            .:.|:..:|||.:                   :|||          :.||...:|. ..||:.:.
Mouse   310 ANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGG-EERAQEIF 373

  Fly   246 NKWIETQKSLIDSFSQAIQNTNQN------VDNIANVYEVME------NLNKNLREL---VILLS 295
            .|:.:.:|..:.:||....|.::.      .:|....||:..      |..:.|..|   ::|..
Mouse   374 AKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAG 438

  Fly   296 DKESFPTTESSSSQQTTSIYATTTFYLTSSTFG----STHPIVD---ENINRVNIMGNLIKGLRN 353
            ||        :...|.|::      ||.:...|    .|.|:.:   ::.|:.|:...||.|:..
Mouse   439 DK--------AKQVQWTNV------YLDALELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMG 489

  Fly   354 IMVQMDETNKTS-------SSTSYTTTESTYI--------------------------------- 378
            :.|.:::..:.:       :...:....:.|:
Mouse   490 VDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNVQNPKSQ 554

  Fly   379 QPSTSTYLNAEVTTSHPTTSTYEVTN-IITDESKIKDMFNLIKGIEDLISQYNGKHKFTST-TSL 441
            :|.|..:|:||:...    ...|:.| :|..||..|....|:|..::   :|..|...|.| |.:
Mouse   555 EPVTLDFLDAELENE----IKVEIRNKMIDGESGEKTFRTLVKSQDE---RYIDKGNRTYTWTPV 612

  Fly   442 TGKSNSREPTMTTYSSAGGITSHSFTTTSPK---TVTTSSSH--STTESSPSHPTTSNYEVTVFD 501
            .|         |.||.|..:.::||.....|   |:|.:.|.  ...:|....|..       |:
Mouse   613 NG---------TDYSLALVLPTYSFYYIKAKLEETITQARSKKGKMKDSETLKPDN-------FE 661

  Fly   502 QDSHKFKVMKNLIKELKGL---------IEHFSDTKNITSTTYSTGDSKSFQPTATTPDSTDRSS 557
            :..:.|...:....:||..         ...|.|.|                    ||::
Mouse   662 ESGYTFIAPREYCNDLKPSDNNTEFLLNFNEFIDRK--------------------TPNN----- 701

  Fly   558 SQPITFPESTTSTTN---LQSTITNHLSTESTSSQLN 591
                  |...|...|   |.:..||.|.....|.|.|
Mouse   702 ------PSCNTDLINRILLDAGFTNELVQNYWSKQKN 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42818	NP_001188821.1	PHA03255	642..>763	CDD:165513
Cacna2d1	XP_011248046.1	VWA_N	104..223	CDD:369855	22/98 (22%)
		vWA_VGCC_like	239..417	CDD:238740	33/187 (18%)
		dCache_1	<437..622	CDD:376917	39/214 (18%)
		VGCC_alpha2	651..1079	CDD:369894	21/120 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900