DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SORBS3 and sorb-1

DIOPT Version :9

Sequence 1:	XP_006716329.1	Gene:	SORBS3 / 10174	HGNCID:	30907	Length:	710	Species:	Homo sapiens
Sequence 2:	NP_001360603.1	Gene:	sorb-1 / 3565590	WormBaseID:	WBGene00012891	Length:	1007	Species:	Caenorhabditis elegans

Alignment Length:	824	Identity:	195/824 - (23%)
Similarity:	295/824 - (35%)	Gaps:	261/824 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    14 PSWEKKEES--------ESDVVLLSPKDP-----------------------DRGHAEEQLACPE 47
            |.:..::||        ||..:|:..|.|                       |...:...||...
Worm   312 PPFSPEKESEIKRSIDLESSQLLVKSKSPAPYSTSSTDHYGTIRRKHKPVAIDLSKSSPNLASQS 376

Human    48 SSHL------------DPSMQGPPRSLRAGL---SLDDFIPGHLQSHIGSSSRGTRFHDPAPRTV 97
            .|:|            .| |...|.....|.   ||:|.:  :....|.||...|:....||.|.
Worm   377 PSNLFFGASFEEKQNRSP-MTSTPSYKEQGFKNDSLNDSL--NQAFEIASSIETTKNAYEAPPTP 438

Human    98 CNGGYTPRRDASQHP-DPAWYQTWPGPGSKPSAST------KIPASQHTQNWSATWTKDSKRRDK 155
            .:..: .|..:..:| ..:...|||...:.|:.:|      .:....:|:....:.:..|.....
Worm   439 KSASH-DRSISDTYPVSSSTTSTWPSHTTTPTTTTAAAPIAAVAPQTYTEQQPMSTSMSSSVMST 502

Human   156 RWVKYEGIGPVDESGMPI-----------APRSSVDRPRD---WYRRMFQQIHRKMPDLQLDWTF 206
            .         :||   ||           :|.||.:|..|   |||:||:|:|||
Worm   503 N---------MDE---PIVVGSHQQIPQQSPDSSPERNEDMSQWYRKMFKQMHRK---------- 545

Human   207 EEPPRDPRHLGAQQRPAH--RPGPATSSSGRSWDHSEELPRS----TFN-YRPGAFSTVLQPSNQ 264
               ..|..:.|.:|   |  .|...|...||:...:..|.||    :|| :||.      .||:
Worm   546 ---GEDGSNEGKEQ---HFINPSNVTDGIGRTTPTASNLGRSRENLSFNQHRPD------HPSS- 597

Human   265 VLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELAELSAE-LDKD 328
                               :...||.|  |.....:....|.|.      |.||..|.|| |.::
Worm   598 -------------------YFDSLEHG--PNDQYNNQERVKQSN------EEELLRLKAEKLAEE 635

Human   329 LRAIETRLPS--PKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLG 391
            ||..:.|..|  |.|:|:.:...::                                      |.
Worm   636 LRKEKERKHSFIPSSAPSLQNNMDR--------------------------------------LN 662

Human   392 RRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 456
            ...:.:.|..::|:..:....|.       ..|...:.|:.:|.:||.|.:|||:.|.:|||..|
Worm   663 SLLYDFSSDIQEPAHRDYTPQPV-------MTATAVYKFEPRSARELPLNRGDIIRIIREVDGYW 720

Human   457 LEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAV---AQYTFKGDLEVELSFRKGE 518
            :|||.:||.||||.:||::...::               |::.   |.|.|....:.|||.::||
Worm   721 MEGERNGRSGIFPTSYVQINTGNQ---------------GDSQKMRAIYPFTARSDTELSLKRGE 770

Human   519 HICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRL-TAAARSARHP 582
            .|...|:::.||.||. ...|..||||||||:...:....:....|..|.:|:: .........|
Worm   771 IITRRRQIDSNWLEGS-NQIGIVGIFPASYVEPIEQVEQHIPTIVPNRPKTPKIEDQVYNQVYKP 834

Human   583 SSPSALRSPADPIDLGGQTSPRRTGFSFP------------------------TQEPRPQTQNLG 623
            :....::|.....|........:..|..|                        ||....|..|.|
Worm   835 NETVIMQSNQGYYDKAAVVPNNKVRFDLPSGSDSNLQISRSLNPHQNQFPPTHTQTSTQQPSNYG 899

Human   624 --------------TPGPALSHSR----GPSHP-------LDLGTSSPNTSQIHWTPYRAMYQYR 663
                          .|...:...|    .|.:|       ::..:..|..|::    |||:|.|:
Worm   900 MKKIEYEREKVVEEVPPMHMDQYRKLNDEPKNPKKDTNILMNAASLIPKGSEM----YRAVYPYQ 960

Human   664 PQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 707
            ||.||||:|...|.:.|:::||||||:|.|.||..||.||||||
Worm   961 PQKEDELQLYTNDIIFVVEKCDDGWFIGTSLRTGDFGIFPGNYV 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SORBS3	XP_006716329.1	Sorb	155..204	CDD:128735	18/62 (29%)
		AC_N	337..>412	CDD:292831	7/76 (9%)
		SH3_Vinexin_1	422..476	CDD:212854	25/53 (47%)
		SH3_Vinexin_2	496..551	CDD:212857	24/57 (42%)
		SH3_Vinexin_3	653..710	CDD:212851	32/55 (58%)
sorb-1	NP_001360603.1	Sorb	505..553	CDD:383053	19/63 (30%)
		SH3_Sorbs_1	687..739	CDD:212715	25/51 (49%)
		SH3_Sorbs_1	749..802	CDD:212715	23/53 (43%)
		SH3_Sorbs_3	952..1006	CDD:212714	32/57 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161457401
Domainoid	1	1.000	79	1.000	Domainoid score	I6079
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123083at33208
OrthoFinder	1	1.000	-	-		FOG0004115
OrthoInspector	1	1.000	-	-		otm16497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8484
SonicParanoid	1	1.000	-	-		X3387
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.880