DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF256 and CG11247

DIOPT Version :9

Sequence 1:	NP_005764.2	Gene:	ZNF256 / 10172	HGNCID:	13049	Length:	627	Species:	Homo sapiens
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	114/396 - (28%)
Similarity:	169/396 - (42%)	Gaps:	85/396 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   230 QGDLIRERSYMCSECGKSFSTSCSLSDHLRVHTSEKPYTCGECGKSYRQSSSLITH-RRIHTGVR 293
            :|:.::.:.::||:|.|.|.....|..|:.:|:.|:|:.|.:|||||||:.:|..| ...|...:
  Fly    84 KGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRK 148

Human   294 PHQCDECGKLFNRKYDLLIHQRVHTGERPYKCSECGKSFSHSSSLITHQRIH--TGMRPYECSEC 356
            ...|.:|.|.|..|..|.:|.|:|:||:||.|..|.|.|:....|..|...|  |.::.:.|::|
  Fly   149 QFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKC 213

Human   357 GKSFIHSSSLITHQRVHTGTRPYMCSECGKSFSQSCHLIKHRRLHIGEGPYECSECGKLFTYRSR 421
            ..||..:::|..|...|.....:.||.|...|:....|    |.||.:
  Fly   214 SASFSTNANLRVHMERHEQGMEHRCSICENQFANELAL----RAHINQ----------------- 257

Human   422 FFQHQRVHTGVRSHECHECGKLFSRKFDLIVHERVHTGERPYECSECGKSFTCKSYLISHWKVHT 486
              :|.:    :...||..|.|:.....||..|.:.||..:.:.|..|...||.||....|.::||
  Fly   258 --EHHK----LTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHT 316

Human   487 GARPYECGECGKSFTHSSTLLQHQRVHTGERPYECNECGKFFSQSSSLIRHRRSHTGERPYECSE 551
            |.|||:|..|.::|.|||.|..|.|.||||:|:.|..|
  Fly   317 GERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLC--------------------------- 354

Human   552 CWKSFSNHSSLVKHRRVHTGERPYECSECGKSFSQSSNLTNH-QRIHSGERPYECSDCGKFFTFN 615
                                       |...:|||.::|.|| ::||..::||.|..|..||...
  Fly   355 ---------------------------EDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIK 392

Human   616 SNLLKH 621
            ..|..|
  Fly   393 VELQSH 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF256	NP_005764.2	KRAB	14..54	CDD:366587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..76
		C2H2 Zn finger	215..233	CDD:275368	1/2 (50%)
		C2H2 Zn finger	241..261	CDD:275368	7/19 (37%)
		C2H2 Zn finger	269..289	CDD:275368	10/20 (50%)
		COG5048	293..626	CDD:227381	92/332 (28%)
		C2H2 Zn finger	297..317	CDD:275368	8/19 (42%)
		C2H2 Zn finger	325..345	CDD:275368	6/19 (32%)
		C2H2 Zn finger	353..373	CDD:275368	6/19 (32%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		C2H2 Zn finger	409..429	CDD:275368	1/19 (5%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	493..513	CDD:275368	9/19 (47%)
		C2H2 Zn finger	521..541	CDD:275368	2/19 (11%)
		C2H2 Zn finger	549..569	CDD:275368	0/19 (0%)
		C2H2 Zn finger	577..597	CDD:275368	7/20 (35%)
		C2H2 Zn finger	605..625	CDD:275368	6/17 (35%)
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	53/158 (34%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	10/20 (50%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	63/257 (25%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	8/44 (18%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..374	CDD:275368	9/76 (12%)
		C2H2 Zn finger	382..399	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910