Protein Alignment CDK2 and Cdk9

DIOPT Version :10

• Sequence 1: XP_011536034.1
• Gene: CDK2 / 1017
• HGNCID: 1771
• Length: 346
• Species: Homo sapiens
• Sequence 2: NP_477226.2
• Gene: Cdk9 / 37586
• FlyBaseID: FBgn0019949
• Length: 404
• Species: Drosophila melanogaster
• Alignment Length: 361
• Identity: 139/361 - (38%)
• Similarity: 186/361 - (51%)
• Gaps: 79/361 - (21%)

Human     4 FQKVEKIGEGTYGVVYKARNKL-TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67
            ::||.|||:||:|.|:|||.|. ..:.||:||:.:|.|.||.|.||:|||.:|:.|.|.|:|.|:
  Fly    50 YEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVNLI 114

Human    68 DVIHTE--------NKLYLVFEFLHQDLKKFMDASALTGI----PLPLIKSYLFQLLQGLAFCHS 120
            ::..|:        :..||||:|...||     |..|:.:    .|..||..:.|||.||.:.||
  Fly   115 EICRTKATATNGYRSTFYLVFDFCEHDL-----AGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHS 174

Human   121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP----VRTYTHEVVTLWYRAPEILLGCKYYS 181
            :::||||:|..|:||...|.:|||||||||||.:|    ...||:.|||||||.||:|||.:.|.
  Fly   175 NKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYG 239

Human   182 TAVDIWSLGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVT 246
            ..||:|..|||.|||                                     |           |
  Fly   240 PPVDMWGAGCIMAEM-------------------------------------W-----------T 256

Human   247 RRALFPGDSEIDQLFRIFRTLG--TPDEVVWPGVTSMPDYKP-SFPKWARQDFSKVVPPL--DED 306
            |..:..|::|..||..|.:..|  |||  |||||..:..||. ..||..::...:.:.|.  |:.
  Fly   257 RSPIMQGNTEQQQLTFISQLCGSFTPD--VWPGVEELELYKSIELPKNQKRRVKERLRPYVKDQT 319

Human   307 GRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 342
            |..||.::|..||.|||.|..||.|.||.  |.|:|
  Fly   320 GCDLLDKLLTLDPKKRIDADTALNHDFFW--TDPMP 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK2	XP_011536034.1	STKc_CDK2_3	3..334	CDD:270844	134/351 (38%)
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	134/351 (38%)